ArticleCrystal growth & design2017
Multidrug Cocrystal of Anticonvulsants: Influence of Strong Intermolecular Interactions on Physiochemical Properties.
Article in Crystal growth & design, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Improving the Solubility and Bioavailability of Progesterone Cocrystals with Selected Carboxylic Acids.Pharmaceutics · 2024Article
- Complementary supramolecular drug associates in perfecting the multidrug therapy against multidrug resistant bacteria.Frontiers in immunology · 2024Article
- Cocrystals by Design: A Rational Coformer Selection Approach for Tackling the API Problems.Pharmaceutics · 2023Review
- Exploring the Non-Covalent Bonding in Water Clusters.International journal of molecular sciences · 2023Article
- Virtual Screening, Structural Analysis, and Formation Thermodynamics of Carbamazepine Cocrystals.Pharmaceutics · 2023Article
- Melt Crystallization of Celecoxib-Carbamazepine Cocrystals with the Synchronized Release of Drugs.Pharmaceutical research · 2023Article
- Dual Antimelanogenic Effect of Nicotinamide-Stabilized Phloretin Nanocrystals in Larval Zebrafish.Pharmaceutics · 2022Article
- Comparison of Proton Acceptor and Proton Donor Properties of HMolecules (Basel, Switzerland) · 2022Article
- Drug-drug cocrystals: Opportunities and challenges.Asian journal of pharmaceutical sciences · 2021Review
- Synthesis and structure of a 1:1 co-crystal of hexa-methyl-ene-tetra-mine carb-oxy-borane and acetamino-phen.Acta crystallographica. Section E, Crystallographic communications · 2020Article
- A New Co-Crystal of Synthetic Drug Rosiglitazone with Natural Medicine Berberine: Preparation, Crystal Structures, and Dissolution.Molecules (Basel, Switzerland) · 2020Article
- Crystal Structures, Stability, and Solubility Evaluation of a 2:1 Diosgenin-Piperazine Cocrystal.Natural products and bioprospecting · 2020Article
- Pharmaceutical solvate formation for the incorporation of the antimicrobial agent hydrogen peroxide.Chemical communications (Cambridge, England) · 2018Article
- Engineering Cocrystals of PoorlyWater-Soluble Drugs to Enhance Dissolution in Aqueous Medium.Pharmaceutics · 2018Review
- Cocrystal Solubility Product Prediction Using an in combo Model and Simulations to Improve Design of Experiments.Pharmaceutical research · 2018Article
- Understanding the Differences Between Cocrystal and Salt Aqueous Solubilities.Journal of pharmaceutical sciences · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
A drug-drug cocrystal of two anticonvulsants, lamotrigine and phenobarbital, is presented. In the crystal structure, molecules form heterodimers via N-H···O and N-H···N hydrogen bonding. The intrinsic dissolution rate (IDR) and solubility of the cocrystal were measured in phosphate buffer (pH 7.2) and simulated gastric fluid (without pepsin), and compared to pure APIs. Dissolution experiments found suppressed IDR of the cocrystal with rates in the order pure PB > pure LTG > cocrystal. The solubility measurements were consistent with the dissolution behavior. The presence of strong heterodimers in the cocrystal compared to weaker homodimers in the parent drugs is implicated for the reduced solubility and dissolution rate.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.