Evidence map›Paper›PMID 31537946›Full record

ArticleJournal of fluorine chemistry2019

Recent progress in the strategic incorporation of fluorine into medicinally active compounds.

Krupanandan Haranahalli, Tadashi Honda, Iwao Ojima

Open access · greenAbstract read
In one paragraph

Article in Journal of fluorine chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
  2. Micronutrient Status and Breast Cancer: A Narrative Review.International journal of molecular sciences · 2024
    Review
  3. Article
  4. Discovery of novel mRNA demethylase FTO inhibitors against esophageal cancer.Journal of enzyme inhibition and medicinal chemistry · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Enantioselective 5-Molecules (Basel, Switzerland) · 2019
    Article
  11. Recent Studies on Fluorinated Silica Nanometer-Sized Particles.Nanomaterials (Basel, Switzerland) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Krupanandan HaranahalliInstitute of Chemical Biology & Drug Discovery, Stony Brook University-State University of New York, Stony Brook, NY, 11794-3400, U.S. A.
Tadashi HondaDepartment of Chemistry, Stony Brook University-State University of New York, Stony Brook, NY, 11794-3400, U. S. A.
Iwao OjimaDepartment of Chemistry, Stony Brook University-State University of New York, Stony Brook, NY, 11794-3400, U. S. A.
Stony Brook University · USState University of New York · US

Funding

New antifungals targeting the synthesis of fungal sphingolipidsR01AI116420 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI Maurizio Del Poeta · 2016 to 2026
$7.6M
Lipid-mediated fungal pathogenesisR01AI125770 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI DEL POETA, MAURIZIO · 2016 to 2025
$6.2M
Tumor -Targeting Chemotherapeutic AgentsR01CA103314 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI OJIMA, IWAO · 2003 to 2013
$3.1M
Targeting the PEX Domain of MT1-MMP: Novel Cancer TherapyR01CA113553 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI CAO, JIAN · 2006 to 2010
$1.7M
Integrating Anti-invasive and Anti-growth Therapies Targeting Cancer MetastasisR01CA166936 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI SAMPSON, NICOLE S · 2012 to 2016
$1.6M
NCI NIH HHS R01 CA103314NCI NIH HHS R01 CA113553NCI NIH HHS R01 CA166936NIAID NIH HHS R01 AI116420NIAID NIH HHS R01 AI125770
6 · The paper itself

Abstract

This account exemplifies our recent progress on the strategic incorporation of fluorine and organofluorine groups to (i) taxoid anticancer agents, (ii) acylhydrazone-based antifungal agents and (iii) inhibitors of matrix metalloproteinase 9 (MMP9) for medicinal chemistry and chemical biology studies. In the case study (i), a series of next-generation fluorotaxoids, bearing

Indexed as

AcylhydrazoneAnticancer agentAntifungal agentEnzyme inhibitorFluorine-containingMMP9Taxoid

Identifiers

PMID31537946
PMCPMC6752223
OpenAlexW2898631903

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.