ArticleScientific reports2019
Goal-directed vs. habitual instrumental behavior during reward processing in anorexia nervosa: an fMRI study.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- The effects of acute tryptophan depletion on instrumental reward learning in anorexia nervosa - an fMRI study.Psychological medicine · 2023Trial
- Avoidance habit learning in adolescents and young women with anorexia nervosa: an fMRI study.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Reinforcement Learning and Decision Making in Anorexia Nervosa.Current psychiatry reports · 2025Review
- Examining the biological causes of eating disorders to inform treatment strategies.Nature reviews. Neuroscience · 2025Review
- Resting-state functional brain connectivity in female adolescents with first-onset anorexia nervosa.NeuroImage. Clinical · 2025Article
- Neuroimaging studies of resting-state functional magnetic resonance imaging in eating disorders.BMC medical imaging · 2024Review
- A transdiagnostic and translational framework for delineating the neuronal mechanisms of compulsive exercise in anorexia nervosa.The International journal of eating disorders · 2024Review
- Testing the role of associative learning in evidence-based treatments for anorexia nervosa.The International journal of eating disorders · 2024Review
- Habits and Persistent Food Restriction in Patients with Anorexia Nervosa: A Scoping Review.Behavioral sciences (Basel, Switzerland) · 2023Article
- Article
- Learned industriousness as a translational mechanism in anorexia nervosa.Nature reviews psychology · 2023Article
- White matter microstructure in habit and reward circuits in anorexia nervosa: Insights from a neurite orientation dispersion and density imaging study.Acta psychiatrica Scandinavica · 2023Article
- The potential application of event-related potentials to enhance research on reward processes in eating disorders.The International journal of eating disorders · 2022Review
- Increased Habit Frequency in the Daily Lives of Patients with Acute Anorexia Nervosa.Nutrients · 2022Article
- Neural, physiological, and psychological markers of appetitive conditioning in anorexia nervosa: a study protocol.Journal of eating disorders · 2022Article
- Prefrontal contributions to the stability and variability of thought and conscious experience.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Beyond Description and Deficits: How Computational Psychiatry Can Enhance an Understanding of Decision-Making in Anorexia Nervosa.Current psychiatry reports · 2022Review
- White matter tracts characteristics in habitual decision-making circuit underlie ritual behaviors in anorexia nervosa.Scientific reports · 2021Article
- From Desire to Dread-A Neurocircuitry Based Model for Food Avoidance in Anorexia Nervosa.Journal of clinical medicine · 2021Review
- Exploring Neural Mechanisms Related to Cognitive Control, Reward, and Affect in Eating Disorders: A Narrative Review of FMRI Studies.Neuropsychiatric disease and treatment · 2021Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have proposed that altered reward processing and elevated cognitive control underlie the etiology of anorexia nervosa (AN). A newly debated notion suggests altered habit learning and an overreliance on habits may contribute to the persistence of AN. In weight-recovered AN patients, we previously found neuroimaging-based evidence for unaltered reward processing, but elevated cognitive control. In order to differentiate between state versus trait factors, we here contrast the aforementioned hypotheses in a sample of acutely underweight AN (acAN) patients. 37 acAN patients and 37 closely matched healthy controls (HC) underwent a functional MRI while performing an established instrumental motivation task. We found no group differences with respect to neural responses during the anticipation or receipt of reward. However, the behavioral response data showed a bimodal distribution, indicative for a goal-directed (gAN) and a habit-driven (hAN) patient subgroup. Additional analyses revealed decreased mOFC activation during reward anticipation in hAN, which would be in line with a habit-driven response. These findings provide a new perspective on the debate regarding the notion of increased goal-directed versus habitual behavior in AN. If replicable, the observed dissociation between gAN and hAN might help to tailor therapeutic approaches to individual patient characteristics.
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