ArticleScientific reports2019
Metagenomic deep sequencing reveals association of microbiome signature with functional biases in bovine mastitis.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.
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Who cites it
103 citing papers in PubMed, 199 citations in OpenAlex.
- Subclinical Mastitis and Antibiotic Exposure Reshape the Milk Bacteriome, Resistome, and Metabolic Functional Profiles in Dairy Cows.MicrobiologyOpen · 2026Article
- Draft genome sequence ofMicrobiology resource announcements · 2026Article
- Multi-Layer Transcriptome Analysis Uncovers Molecular Signatures of Coliform Mastitis in Lactating Cows.International journal of molecular sciences · 2026Article
- Analysis of Bacterial Diversity in Fresh Milk from Commercial Dairy Farms in Xinjiang Based on Metagenomic Sequencing.Veterinary sciences · 2026Article
- Genomic Insights Into Antimicrobial Resistance and Virulence of Enterococcus avium Strains From Bovine Mastitis in Some Selected Dairy Farms of Bangladesh.Veterinary medicine and science · 2026Article
- Urbanization shapes gut bacterial communities and metabolic functions in migratory wild birds across Bangladesh.BMC microbiology · 2026Article
- Antimicrobial Resistance, Virulence Factors and Plasmid Replicon Patterns ofAntibiotics (Basel, Switzerland) · 2026Article
- Bacteriome and resistome dysbiosis in subclinical mastitis and antibiotic-treated milk of dairy cows.Microbiology resource announcements · 2026Article
- Shotgun metagenomic profiling reveals Bacillus-dominated bacterial communities in urban rooftop and surface garden soils of Bangladesh.PloS one · 2026Article
- Longitudinal study of mammary microbiota dynamics and mastitis prevention in Holstein cows by dry-off strategy.Frontiers in veterinary science · 2026Article
- Characterisation of the bacterial and archaeal microbiota in processed colostrum collected from a spring-calving dairy herd.PloS one · 2026Article
- Metataxonomic insights into lactic acid bacteria diversity in artisanal coalho cheese from the Caatinga biome.PloS one · 2026Article
- Longitudinal study of the udder microbiome using genome-centric metagenomics uncovers pathogen-driven adaptation and succession.NPJ biofilms and microbiomes · 2025Article
- The Microbial Composition of Bovine Colostrum as Influenced by Antibiotic Treatment.Antibiotics (Basel, Switzerland) · 2025Article
- Assessment of bacterial diversity in bovine bulk tank milk samples from Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Using metagenomics and whole-genome sequencing to characterize enteric pathogens across various sources in Africa.Nature communications · 2025Article
- Targeting the Gut-Mammary Axis for Understanding Mastitis Pathogenesis and Therapeutic Strategies.Veterinary sciences · 2025Review
- Microbiome study of Murrah buffalo mastitis milk with emphasis on Acinetobacter species.BMC microbiology · 2025Article
- Impact of Milk-Derived Microbial Transfer and 7-Epiclusianone on Pathogen Load in Goat Mastitis.Current microbiology · 2025Article
- Genomic and Computational Analysis Unveils Bacteriocin Based Therapeutics against Clinical Mastitis Pathogens in Dairy Cows.Probiotics and antimicrobial proteins · 2025Article
43 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Milk microbiomes significantly influence the pathophysiology of bovine mastitis. To assess the association between microbiome diversity and bovine mastitis, we compared the microbiome of clinical mastitis (CM, n = 14) and healthy (H, n = 7) milk samples through deep whole metagenome sequencing (WMS). A total of 483.38 million reads generated from both metagenomes were analyzed through PathoScope (PS) and MG-RAST (MR), and mapped to 380 bacterial, 56 archaeal, and 39 viral genomes. We observed distinct shifts and differences in abundance between the microbiome of CM and H milk in phyla Proteobacteria, Bacteroidetes, Firmicutes and Actinobacteria with an inclusion of 68.04% previously unreported and/or opportunistic strains in CM milk. PS identified 363 and 146 bacterial strains in CM and H milk samples respectively, and MR detected 356 and 251 bacterial genera respectively. Of the identified taxa, 29.51% of strains and 63.80% of genera were shared between both metagenomes. Additionally, 14 archaeal and 14 viral genera were found to be solely associated with CM. Functional annotation of metagenomic sequences identified several metabolic pathways related to bacterial colonization, proliferation, chemotaxis and invasion, immune-diseases, oxidative stress, regulation and cell signaling, phage and prophases, antibiotic and heavy metal resistance that might be associated with CM. Our WMS study provides conclusive data on milk microbiome diversity associated with bovine CM and its role in udder health.
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