Evidence map›Paper›PMID 31537823›Full record

ArticleScientific reports2019

Microarray-based screening system identifies temperature-controlled activity of Connexin 26 that is distorted by mutations.

Hongling Wang, Frank Stahl, Thomas Scheper, Melanie Steffens, Athanasia Warnecke, Carsten Zeilinger

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. A Chemical Chaperone Restores Connexin 26 Mutant Activity.ACS pharmacology & translational science · 2023
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hongling WangHannover Medical School, Department of Otorhinolaryngology, Head- and Neck-Surgery, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Frank StahlGottfried-Wilhelm-Leibniz University of Hannover, Institut für Technische Chemie/BMWZ (Zentrum für Biomolekulare Wirkstoffe), Callinstr. 5, 30167, Hannover, Germany.
Thomas ScheperGottfried-Wilhelm-Leibniz University of Hannover, Institut für Technische Chemie/BMWZ (Zentrum für Biomolekulare Wirkstoffe), Callinstr. 5, 30167, Hannover, Germany.ORCID http://orcid.org/0000-0003-1535-4584
Melanie SteffensHannover Medical School, Department of Otorhinolaryngology, Head- and Neck-Surgery, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Athanasia WarneckeHannover Medical School, Department of Otorhinolaryngology, Head- and Neck-Surgery, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Carsten ZeilingerGottfried-Wilhelm-Leibniz University of Hannover, BMWZ (Zentrum für Biomolekulare Wirkstoffe), Schneiderberg 38, 30167, Hannover, Germany. zeilinger@cell.uni-hannover.de.
Leibniz University Hannover · DEMedizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here, we show that human Connexin 26 (hCx26 or Cx26WT) hemichannel opening rapidly enables the transport of small molecules when triggered by temperature and by compensation of the Ca

Indexed as

AnimalsCalciumConnexin 26Gap JunctionsHumansIon Channel GatingOligonucleotide Array Sequence AnalysisOocytesPorinsProtein TransportTemperatureXenopusCalciumConnexin 26Porins

Identifiers

PMID31537823
PMCPMC6753059
OpenAlexW2973292896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.