ArticleScientific reports2019
Functional organization of motor networks in the lumbosacral spinal cord of non-human primates.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Recurrent Cystolithiasis with Urethral Obstruction in a Rhesus Macaque (Macaca mulatta) after a Bilateral S1 Ventral Root Avulsion Injury.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- A fully implantable intraspinal microstimulation device for early preclinical evaluation of feasibility, stability, and functionality.Scientific reports · 2026Article
- [Closed-loop regulation system for paralyzed lower limb joint movement based on electrical stimulation of spinal central pattern generator].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Article
- Functional motor mapping of domestic pig lumbar spinal cord using penetrating microelectrodes.Journal of neuroengineering and rehabilitation · 2025Article
- Remote neurodegeneration in the lumbosacral cord one month after spinal cord injury: a cross-sectional MRI study.Annals of clinical and translational neurology · 2025Article
- Targeted Selection of Stimulation Parameters for Restoration of Motor and Autonomic Function in Individuals With Spinal Cord Injury.Neuromodulation : journal of the International Neuromodulation Society · 2024Article
- Article
- Spinal maps of motoneuron activity during human locomotion: neuromechanical considerations.Frontiers in physiology · 2024Review
- Composite Fibrin/Carbon Microfiber Implants for Bridging Spinal Cord Injury: A Translational Approach in Pigs.International journal of molecular sciences · 2023Article
- A wireless spinal stimulation system for ventral activation of the rat cervical spinal cord.Scientific reports · 2021Article
- Comparative neuroanatomy of the lumbosacral spinal cord of the rat, cat, pig, monkey, and human.Scientific reports · 2021Article
- Intraspinal stimulation with a silicon-based 3D chronic microelectrode array for bladder voiding in cats.Journal of neural engineering · 2020Article
- Combined Supra- and Sub-Lesional Epidural Electrical Stimulation for Restoration of the Motor Functions after Spinal Cord Injury in Mini Pigs.Brain sciences · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
Implantable spinal-cord-neuroprostheses aiming to restore standing and walking after paralysis have been extensively studied in animal models (mainly cats) and have shown promising outcomes. This study aimed to take a critical step along the clinical translation path of these neuroprostheses, and investigated the organization of the neural networks targeted by these implants in a non-human primate. This was accomplished by advancing a microelectrode into various locations of the lumbar enlargement of the spinal cord, targeting the ventral horn of the gray matter. Microstimulation in these locations produced a variety of functional movements in the hindlimb. The resulting functional map of the spinal cord in monkeys was found to have a similar overall organization along the length of the spinal cord to that in cats. This suggests that the human spinal cord may also be organized similarly. The obtained spinal cord maps in monkeys provide important knowledge that will guide the very first testing of these implants in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.