Evidence map›Paper›PMID 31537705›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Impairment of Sharp-Wave Ripples in a Murine Model of Dravet Syndrome.

Christine S Cheah, Brian N Lundstrom, William A Catterall, John C Oakley

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Christine S CheahDepartments of Neurology.
Brian N LundstromDepartment of Neurology, Mayo Clinic, Rochester, Minnesota 55905.
William A CatterallPharmacology, University of Washington, Seattle, Washington 98195, and.
John C OakleyDepartments of Neurology, jcoakley@uw.edu.
University of Washington · USMayo Clinic · US

Funding

Pharmacological Sciences SupplementT32GM007750 · NIGMS · UNIVERSITY OF WASHINGTON · PI ATKINS, WILLIAM M · 1985 to 2023
$12.6M
CELL BIOLOGY OF THE NEURONAL SODIUM CHANNELR01NS025704 · NINDS · UNIVERSITY OF WASHINGTON · PI CATTERALL, WILLIAM A · 1988 to 2018
$6.2M
Hippocampal sharp – wave ripple disruption and spatial memory impairment in mouse models of Dravet syndromeR01NS094186 · NINDS · UNIVERSITY OF WASHINGTON · PI OAKLEY, JOHN C · 2016 to 2020
$1.7M
Brain regions contributing to seizures as a function of age and body temperatureK08NS071193 · NINDS · UNIVERSITY OF WASHINGTON · PI OAKLEY, JOHN C · 2011 to 2015
$888k
NIGMS NIH HHS T32 GM007750NINDS NIH HHS K08 NS071193NINDS NIH HHS R01 NS025704NINDS NIH HHS R01 NS094186
6 · The paper itself

Abstract

Dravet syndrome (DS) is a severe early-onset epilepsy associated with heterozygous loss-of-function mutations in

Indexed as

Brain WavesAnimalsDisease Models, AnimalEpilepsies, MyoclonicFemaleGABAergic NeuronsHaploinsufficiencyHippocampusInterneuronsMaleMice, Inbred C57BLModels, NeurologicalNAV1.1 Voltage-Gated Sodium ChannelNeuronsNAV1.1 Voltage-Gated Sodium ChannelScn1a protein, mousechannelopathyDravet syndromeepilepsy comorbiditylearning and memoryScn1asharp-wave ripple

Identifiers

PMID31537705
PMCPMC6855681
OpenAlexW2974434632

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.