Evidence map›Paper›PMID 31537691›Full record

ArticleHaematologica2020

Clinical applications of donor lymphocyte infusion from an HLA-haploidentical donor: consensus recommendations from the Acute Leukemia Working Party of the EBMT.

Bhagirathbhai Dholaria, Bipin N Savani, Myriam Labopin, Leo Luznik, Annalisa Ruggeri, Stephan Mielke, Monzr M Al Malki, Piyanuch Kongtim, Ephraim Fuchs, Xiao-Jun Huang and 29 more

Open access · goldAbstract readConsensus Statement
In one paragraph

Article in Haematologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 86 citations in OpenAlex.

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  8. Posttransplant cells for the win? DLI and adoptive cell therapy to eradicate MRD.Hematology. American Society of Hematology. Education Program · 2025
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  15. "Attack!" Cellular Therapies to Attack Pathogens and Tumors.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors at 20 institutions in 14 countries.

Bhagirathbhai DholariaDepartment of Hematology-Oncology, Vanderbilt University Medical Center, Nashville, TN, USA bhagirathbhai.r.dholaria@vumc.org.
Bipin N SavaniDepartment of Hematology-Oncology, Vanderbilt University Medical Center, Nashville, TN, USA.
Myriam LabopinDepartment of Haematology and EBMT Paris study office / CEREST-TC, Saint Antoine Hospital, Paris, France.
Leo LuznikDepartment of Oncology Hematologic Malignancies, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Annalisa RuggeriDepartment of Pediatric Hematology/Oncology and Cell and Gene Therapy, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.
Stephan MielkeDepartment of Laboratory Medicine, CAST, Karolinska Institutet and University Hospital, Stockholm, Sweden.
Monzr M Al MalkiDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA.
Piyanuch KongtimStem Cell Transplant and Cellular Therapy, Thammasat University, Pathumthani, Thailand.
Ephraim FuchsJohns Hopkins University, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.
Xiao-Jun HuangPeking University People's Hospital, Peking University Institute of Hematology, Beijing China.
Franco LocatelliDepartment of Pediatric Hematology/Oncology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Sapienza, University of Rome, Italy.
Franco AversaDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Luca CastagnaInstituto Clinico Humanitas, Rozzano Milano, Italy.
Andrea BacigalupoFondazione Policlinico Universitario Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Massimo MartelliUniversity of Perugia, Sant'Andrea Delle Fratte, Perugia Italy.
Didier BlaiseDepartment of Hematology, Institut Paoli Calmettes, Marseille France.
Patrick Ben SoussanDepartment of Clinical Psychology, Paoli-Calmettes Institute, Marseille, France.
Yolande ArnaultInstitut Paoli-Calmette, département de psychologie clinique, Marseille, France.
Rupert HandgretingerDepartment of Hematology and Oncology, University Children's Hospital Tübingen, Tübingen Germany.
Denis-Claude RoyDivision of Hematology and Medical Oncology, Hospital Maisonneuve-Rosemont, Montreal, QC, Canada.
Paul O'DonnellHematology-Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Asad BasheyBlood and Marrow Transplant Program at Northside Hospital, Atlanta, GA, USA.
Scott SolomonBlood and Marrow Transplant Program at Northside Hospital, Atlanta, GA, USA.
Rizwan RomeeDana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Philippe LewalleHematology Department, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
Jorge GayosoHGU Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
Michael MaschanOncology and immunology, Dmitriy Rogachev National Medical Center of pediatric hematology, Moscow, Russia.
Hillard M LazarusAdult Hematologic Malignancies & Stem Cell Transplant Section, University Hospitals Seidman Cancer Center, Cleveland, OH, USA.
Karen BallenDivision of hematology/oncology, University of Virginia Health System, Charlottesville, VA, USA.
Sebastian GiebelDept. of Bone Marrow Transplantation and Onco-Hematology, Maria Sklodowska-Curie Institute - Oncology Center, Gliwice Branch, Gliwice, Poland.
Frederic BaronLaboratory of Hematology, University of Liège, Liège, Belgium.
Fabio CiceriHematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milano Italy.
Jordi EsteveHematology department, Hospital Clínic de Barcelona, Barcelona Spain.
Norbert-Claude GorinService d'hématologie et thérapie cellulaire Centre international greffes APHP-EBMT-INCa Hospital, Saint Antoine Hospital, Paris France.
Alexandros SpyridonidisBone Marrow Transplantation Unit and CBMDP Donor Center, University Hospital of Patras, Patras, Greece.
Christoph SchmidDepartment of Hematology and Oncology, Klinikum Augsburg, Augsburg, Germany.
Stefan O CiureaStem Cell Transplant and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Arnon NaglerChaim Sheba Medical Center, Tel Aviv University, Tel-Hashomer, Israel and EBMT ALWP office, Saint Antoine Hospital, Paris, France.
Mohamad MohtyService d'Hématologie Clinique et Thérapie Cellulaire, Hôpital Saint-Antoine, AP-HP, Sorobonne University, and INSERM UMRs 938, Paris, France.
Bambino Gesù Children's Hospital · ITHarvard University · USInstitut Paoli-Calmettes · FRJohns Hopkins University · USNorthside Hospital · USVanderbilt University Medical Center · USAssistance Publique – Hôpitaux de Paris · FRCity Of Hope National Medical Center · USDmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology · RUFondazione Humanitas per la Ricerca · ITGeneral University Hospital of Patras · GRHôpital Maisonneuve-Rosemont · CAHôpital Saint-Antoine · FRHospital Clínic de Barcelona · ESHospital General Universitario Gregorio Marañón · ESInserm · FRInstitut Pprime · FRKarolinska University Hospital · SEPeking University · CNSheba Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Donor lymphocyte infusion has been used in the management of relapsed hematologic malignancies after allogeneic hematopoietic cell transplantation. It can eradicate minimal residual disease or be used to rescue a hematologic relapse, being able to induce durable remissions in a subset of patients. With the increased use of haploidentical hematopoietic cell transplantation, there is renewed interest in the use of donor lymphocytes to either treat or prevent disease relapse post transplant. Published retrospective and small prospective studies have shown encouraging results with therapeutic donor lymphocyte infusion in different haploidentical transplantation platforms. In this consensus paper, finalized on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation, we summarize the available evidence on the use of donor lymphocyte infusion from haploidentical donor, and provide recommendations on its therapeutic, pre-emptive and prophylactic use in clinical practice.

Indexed as

Graft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansLymphocytesProspective StudiesRetrospective Studies

Identifiers

PMID31537691
PMCPMC6939532
OpenAlexW2974306493

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.