ArticleThe Journal of biological chemistry2019
Epidermal growth factor (EGF) triggers nuclear calcium signaling through the intranuclear phospholipase Cδ-4 (PLCδ4).
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Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Gene expression regulation by CaCellular & molecular biology letters · 2026Pooled it
- Regulation of chromatin dynamics by a calcium-dependent nucleoskeleton.The Journal of biological chemistry · 2026Article
- The oily nucleus- role of phospholipids in genome biology: membrane-directed roles and signaling in the nucleoplasm.Cellular and molecular life sciences : CMLS · 2025Review
- Unraveling anti-atherosclerosis mechanism of anthocyanins from Xinjiang wild cherry plum (Prunus divaricata Ledeb) via network pharmacology and molecular docking.Bioresources and bioprocessing · 2025Article
- FGFR3 alterations in bladder cancer: Sensitivity and resistance to targeted therapies.Cancer communications (London, England) · 2024Review
- Phospholipase Cδ-4 (PLCδ4) Acts as a Nuclear Player to Influence Cyclin B Expression in the Embryonal Rhabdomyosarcoma Cell Lines RD and A204.Biomolecules · 2024Article
- Calcium modulates the tethering of BCOR-PRC1.1 enzymatic core to KDM2B via liquid-liquid phase separation.Communications biology · 2024Article
- Decoding how receptor tyrosine kinases (RTKs) mediate nuclear calcium signaling.Advances in biological regulation · 2024Review
- Review
- The Research Progress of Mitochondrial Transplantation in the Treatment of Mitochondrial Defective Diseases.International journal of molecular sciences · 2024Review
- Inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) is overexpressed in cholangiocarcinoma and its expression correlates with S100 calcium-binding protein A4 (S100A4).Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022Article
- The basis of nuclear phospholipase C in cell proliferation.Advances in biological regulation · 2021Review
- Kinase-Catalyzed Biotinylation to Map Cell Signaling Pathways: Application to Epidermal Growth Factor Signaling.Journal of proteome research · 2021Article
- The role of nuclear Ca2+ in maintaining neuronal homeostasis and brain health.Journal of cell science · 2021Review
- Simultaneous readout of multiple FRET pairs using photochromism.Nature communications · 2021Article
- Characterization of neoplastic cells outlining the cystic space of invasive micropapillary carcinoma of the canine mammary gland.BMC veterinary research · 2021Article
- Review
- Targeting positive feedback between BASP1 and EGFR as a therapeutic strategy for lung cancer progression.Theranostics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Marcelo Coutinho de MirandaDepartment of Biochemistry and Immunology, Universidade Federal de Minas Gerais (UFMG), Av. Antonio Carlos, 6627 Belo Horizonte-MG, 31270-901, Brazil.
Michele Angela RodriguesDepartment of Biochemistry and Immunology, Universidade Federal de Minas Gerais (UFMG), Av. Antonio Carlos, 6627 Belo Horizonte-MG, 31270-901, Brazil.
Ana Carolina de Angelis CamposDepartment of Biochemistry and Immunology, Universidade Federal de Minas Gerais (UFMG), Av. Antonio Carlos, 6627 Belo Horizonte-MG, 31270-901, Brazil.
Jerusa Araújo Quintão Arantes FariaDepartment of Physiology Sciences, Universidade Federal do Amazonas, Manaus-AM, 69080-900, Brazil.
Marianna Kunrath-LimaDepartment of Biochemistry and Immunology, Universidade Federal de Minas Gerais (UFMG), Av. Antonio Carlos, 6627 Belo Horizonte-MG, 31270-901, Brazil.
Gregory A MigneryDepartment of Cell and Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153.
Deborah SchechtmanDepartment of Biochemistry, University of São Paulo, Av. Professor Lineu Prestes, 748, São Paulo-SP 05508-900, Brazil.
Alfredo Miranda GoesDepartment of Pathology, Universidade Federal de Minas Gerais (UFMG), Av. Antonio Carlos, 6627 Belo Horizonte-MG, 31270-901, Brazil.
Michael H NathansonSection of Digestive Diseases, Internal Medicine, Yale University, New Haven, Connecticut 06520-8056.ORCID 0000-0001-9964-0160
Dawidson A GomesDepartment of Biochemistry and Immunology, Universidade Federal de Minas Gerais (UFMG), Av. Antonio Carlos, 6627 Belo Horizonte-MG, 31270-901, Brazil dawidson@icb.ufmg.br.ORCID 0000-0001-7714-991X
Universidade Federal de Minas Gerais · BRYale University · USLoyola University Chicago · USUniversidade de São Paulo · BRUniversidade Federal do Amazonas · BR
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MYale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1MTranslational CoreP01DK057751 · NIDDK · YALE UNIVERSITY · PI YANG, XIAOYONG · 2001 to 2020
$25.6MCALCIUM WAVES IN HEPATOCYTES--MECHANISMS AND EFFECTSR01DK045710 · NIDDK · YALE UNIVERSITY · PI NATHANSON, MICHAEL H · 1999 to 2014
$5.7MCa2+ waves in hepatocytes: Mechanisms and effectsR01DK114041 · NIDDK · YALE UNIVERSITY · PI NATHANSON, MICHAEL H · 2018 to 2022
$2.6MMolecular regulation of cholestasis in cholangiocytesR01DK112797 · NIDDK · YALE UNIVERSITY · PI NATHANSON, MICHAEL H · 2018 to 2021
$1.9MA super-resolution microscope for research and educationS10OD020142 · OD · YALE UNIVERSITY · PI NATHANSON, MICHAEL H · 2015 to 2015
$600kA swept-field confocal microscope for live cell imagingS10OD023598 · OD · YALE UNIVERSITY · PI NATHANSON, MICHAEL H · 2017 to 2017
$570kTrafficking of the EGF receptor to the nucleus: Mechanisms and EffectsR03TW008709 · FIC · YALE UNIVERSITY · PI NATHANSON, MICHAEL H · 2012 to 2014
$230kFIC NIH HHS R03 TW008709NCATS NIH HHS UL1 TR001863NIDDK NIH HHS P01 DK057751NIDDK NIH HHS P30 DK034989NIDDK NIH HHS R01 DK045710NIDDK NIH HHS R01 DK112797NIDDK NIH HHS R01 DK114041NIH HHS S10 OD020142NIH HHS S10 OD023598
Abstract
Calcium (Ca
Indexed as
Calcium SignalingCell LineCell NucleusCell ProliferationClathrin Heavy ChainsCyclin ACyclin B1Epidermal Growth FactorErbB ReceptorsHumansHydrolysisInositol 1,4,5-TrisphosphatePhosphatidylinositol 4,5-DiphosphatePhospholipase C deltaPhospholipase C gammaProtein Kinase CClathrin Heavy ChainsCyclin ACyclin B1EGFR protein, humanEpidermal Growth FactorErbB ReceptorsInositol 1,4,5-TrisphosphatePhosphatidylinositol 4,5-DiphosphatePhospholipase C deltaPhospholipase C gammaProtein Kinase CRNA, Small Interferingcalciumcalcium intracellular releaseEGFRepidermal growth factor receptor (EGFR)inositol 1,4,5-trisphosphate (IP3)nucleusphospholipase Cphospholipase Cδ-4proliferationprotein kinase C (PKC)
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.