ArticleHeart (British Cardiac Society)2020
HIV and pericardial fat are associated with abnormal cardiac structure and function among Ugandans.
Article in Heart (British Cardiac Society), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- A Meta-Analysis of Different Types of Cardiac Adipose Tissue in HIV Patients.BioMed research international · 2020Pooled it
- The Association of Mild Kidney Disease With Coronary Artery Disease Is Stronger for People Living With HIV.Journal of acquired immune deficiency syndromes (1999) · 2026Article
- Ambulatory Blood Pressure Patterns and Left Ventricular Mass Index in Tanzanian Adults Living with and without HIV.Global heart · 2026Article
- Article
- Objectively Measured Physical Activity among People with and without HIV in Uganda: Associations with Cardiovascular Risk and Coronary Artery Disease.Global heart · 2025Article
- Incidence and Progression of Diastolic Dysfunction in People With HIV in Tanzania: A Comparative Cohort.JACC. Advances · 2024Article
- Objectively measured physical activity among people with and without HIV in Uganda: associations with cardiovascular risk and coronary artery disease.medRxiv : the preprint server for health sciences · 2024Article
- Adipose Tissue Dysfunction and Energy Balance Paradigms in People Living With HIV.Endocrine reviews · 2024Review
- Ectopic Fat and Cardiac Health in People with HIV: Serious as a Heart Attack.Current HIV/AIDS reports · 2022Review
- Prevention of heart failure, tachyarrhythmias and sudden cardiac death in HIV.Current opinion in HIV and AIDS · 2022Review
- High rate of left ventricular hypertrophy on screening echocardiography among adults living with HIV in Malawi.Open heart · 2022Article
- Subclinical Left Ventricular Systolic Dysfunction in HIV Patients: Prevalence and Associations with Carotid Atherosclerosis and Increased Adiposity.Journal of clinical medicine · 2022Article
- Article
- Sex modifies the association between HIV and coronary artery disease among older adults in Uganda.Journal of the International AIDS Society · 2022Article
- Diastolic dysfunction in people with HIV without known cardiovascular risk factors in Western Kenya.Open heart · 2022Article
- Prevalence and Correlates of Ischemic ECG Findings among Adults With and Without HIV in Tanzania.Global heart · 2022Article
- Sex, HIV Status, and Measures of Cardiac Stress and Fibrosis in Uganda.Journal of the American Heart Association · 2021Article
- Association of Kidney Disease With Abnormal Cardiac Structure and Function Among Ugandans With HIV Infection.Journal of acquired immune deficiency syndromes (1999) · 2021Article
- Positron Emission Tomography to Characterize Dorsocervical Fat Pad Hypertrophy in People With Treated HIV Infection.Journal of acquired immune deficiency syndromes (1999) · 2020Article
- HIV-1 Tat: Role in Bystander Toxicity.Frontiers in cellular and infection microbiology · 2020Review
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 3 countries.
Funding
Abstract
objectivesTo examine the relationship between pericardial fat (PCF) and cardiac structure and function among HIV-infected patients in the sub-Saharan African country of Uganda. People living with HIV (PLHIV) have altered fat distribution and an elevated risk for heart failure. Whether altered quantity and radiodensity of fat surrounding the heart relates to cardiac dysfunction in this population is unknown.
methodsOne hundred HIV-positive Ugandans on antiretroviral therapy were compared with 100 age and sex-matched HIV-negative Ugandans; all were >45 years old with >1 cardiovascular disease risk factor. Subjects underwent ECG-gated non-contrast cardiac CT and transthoracic echocardiography with speckle tracking strain imaging. Multivariable linear and logistic regression models were used to explore the association of PCF with echocardiographic outcomes.
resultsMedian age was 55% and 62% were female. Compared with uninfected controls, PLHIV had lower body mass index (27 vs 30, p=0.02) and less diabetes (26% vs 45%, p=0.005). Median left ventricular (LV) ejection fraction was 67%. In models adjusted for traditional risk factors, HIV was associated with 10.3 g/m
conclusionsIn Uganda, HIV infection, PCF volume and density are associated with abnormal cardiac structure and function.
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Registered trials
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