ArticleGenes & development2019
Planarians recruit piRNAs for mRNA turnover in adult stem cells.
Article in Genes & development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- The stability of m6A-marked transcripts is linked to cell identity in planarians.Nucleic acids research · 2026Article
- Extracellular vesicles mediate stem cell signaling and systemic RNAi in planarians.Science advances · 2026Article
- piR-bmo-796514 facilitates the proliferation of exogenous DNA virus (baculovirus) by targeting the host E3 ubiquitin ligase RNF181.PLoS pathogens · 2026Article
- Implications of Endogenous Small Regulatory RNAs Survey in Mollusks on Gene Silencing Approaches.Marine biotechnology (New York, N.Y.) · 2025Article
- PIWI proteins and piRNAs: key regulators of stem cell biology.Frontiers in cell and developmental biology · 2025Review
- piRNAs are regulators of metabolic reprogramming in stem cells.Nature communications · 2024Article
- Article
- piRNA generation is associated with the pioneer round of translation in stem cells.Nucleic acids research · 2024Article
- Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells.Biomarker research · 2024Review
- Somatic piRNA and PIWI-mediated post-transcriptional gene regulation in stem cells and disease.Frontiers in cell and developmental biology · 2024Review
- Functional genomics in Spiralia.Briefings in functional genomics · 2023Article
- Insights in piRNA targeting rules.Wiley interdisciplinary reviews. RNA · 2023Article
- The PIWI-specific insertion module helps load longer piRNAs for translational activation essential for male fertility.Science China. Life sciences · 2023Article
- Isolation and Library Preparation of Planarian piRNAs.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Genome-Wide Analysis of Planarian piRNAs.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Heterologous reporter expression in the planarianCell reports methods · 2022Article
- Co-option of the piRNA pathway to regulate neural crest specification.Science advances · 2022Article
- A Krüppel-like factor is required for development and regeneration of germline and yolk cells from somatic stem cells in planarians.PLoS biology · 2022Article
- Positional Information and Stem Cells Combine to Result in Planarian Regeneration.Cold Spring Harbor perspectives in biology · 2022Review
- Restoration of DNA integrity and the cell cycle by electric stimulation in planarian tissues damaged by ionizing radiation.Journal of cell science · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
PIWI proteins utilize small RNAs called piRNAs to silence transposable elements, thereby protecting germline integrity. In planarian flatworms, PIWI proteins are essential for regeneration, which requires adult stem cells termed neoblasts. Here, we characterize planarian piRNAs and examine the roles of PIWI proteins in neoblast biology. We find that the planarian PIWI proteins SMEDWI-2 and SMEDWI-3 cooperate to degrade active transposons via the ping-pong cycle. Unexpectedly, we discover that SMEDWI-3 plays an additional role in planarian mRNA surveillance. While SMEDWI-3 degrades numerous neoblast mRNAs in a homotypic ping-pong cycle, it is also guided to another subset of neoblast mRNAs by antisense piRNAs and binds these without degrading them. Mechanistically, the distinct activities of SMEDWI-3 are primarily dictated by the degree of complementarity between target mRNAs and antisense piRNAs. Thus, PIWI proteins enable planarians to repurpose piRNAs for potentially critical roles in neoblast mRNA turnover.
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Registered trials
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