ArticleGenetics2019
Extending Tests of Hardy-Weinberg Equilibrium to Structured Populations.
Article in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Identification ofFrontiers in veterinary science · 2026Article
- Coancestry superposed on admixed populations yields measures of relatedness at individual-level resolution.PLoS computational biology · 2025Article
- Effects of ACOT7 gene variants on productive performance in Qiandongnan small Xiang goats.Scientific reports · 2025Article
- Introgression dynamics of sex-linked chromosomal inversions shape the Malawi cichlid radiation.Science (New York, N.Y.) · 2025Article
- Multi-ancestry genome-wide association analyses: a comparison of meta- and mega-analyses in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study.BMC genomics · 2025Article
- Semi-supervised machine learning method for predicting homogeneous ancestry groups to assess Hardy-Weinberg equilibrium in diverse whole-genome sequencing studies.American journal of human genetics · 2024Article
- Efficient test for deviation from Hardy-Weinberg equilibrium with known or ambiguous typing in highly polymorphic loci.Briefings in bioinformatics · 2024Article
- Population history modulates the fitness effects of Copy Number Variation in the Roma.Human genetics · 2023Article
- AmelHap: Leveraging drone whole-genome sequence data to create a honey bee HapMap.Scientific data · 2023Article
- Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings.PLoS genetics · 2023Article
- Robust, flexible, and scalable tests for Hardy-Weinberg equilibrium across diverse ancestries.Genetics · 2021Article
- Detection of selection signatures in farmed coho salmon (Oncorhynchus kisutch) using dense genome-wide information.Scientific reports · 2021Article
- A Likelihood-Free Estimator of Population Structure Bridging Admixture Models and Principal Components Analysis.Genetics · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Testing for Hardy-Weinberg equilibrium (HWE) is an important component in almost all analyses of population genetic data. Genetic markers that violate HWE are often treated as special cases; for example, they may be flagged as possible genotyping errors, or they may be investigated more closely for evolutionary signatures of interest. The presence of population structure is one reason why genetic markers may fail a test of HWE. This is problematic because almost all natural populations studied in the modern setting show some degree of structure. Therefore, it is important to be able to detect deviations from HWE for reasons other than structure. To this end, we extend statistical tests of HWE to allow for population structure, which we call a test of "structural HWE." Additionally, our new test allows one to automatically choose tuning parameters and identify accurate models of structure. We demonstrate our approach on several important studies, provide theoretical justification for the test, and present empirical evidence for its utility. We anticipate the proposed test will be useful in a broad range of analyses of genome-wide population genetic data.
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