Evidence map›Paper›PMID 31537610›Full record

ArticleBMJ case reports2019

Primary neuroendocrine carcinoma of the brain.

Clay T Reed, Narjust Duma, Thorvardur Halfdanarson, Jan Buckner

Abstract readCase Reports
In one paragraph

Article in BMJ case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Clay T ReedInternal Medicine, Mayo Clinic, Rochester, Minnesota, USA.ORCID http://orcid.org/0000-0001-9671-5219
Narjust DumaMedical Oncology, Mayo Clinic, Rochester, Minnesota, USA.
Thorvardur HalfdanarsonMedical Oncology, Mayo Clinic, Rochester, Minnesota, USA.
Jan BucknerMedical Oncology, Mayo Clinic, Rochester, Minnesota, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroendocrine neoplasms (NENs) are malignancies with rare reports of central nervous system development. A 34-year-old woman was found to have a primary NEN of the brain, and she had recurrence with identical histology 10 years later. Extracranial NENs were excluded. She had routine surveillance for the first 5 years with MRIs and positron emission tomography/CTs after the initial presentation which was treated with radiation followed by cisplatin and etoposide. This case highlights the difference in primary NENs versus NEN metastases to the brain, and that longer periods of surveillance are likely required for primary NENs. This is important because the prognosis between primary NENs and metastatic NENs to the brain are vastly different and should not be treated as equal diseases. The patient eventually died of her recurrence secondary to complications of a ventriculoperitoneal shunt placed for treatment of hydrocephalus from the disease.

Indexed as

AdultAntineoplastic AgentsCarcinoma, NeuroendocrineCentral Nervous System NeoplasmsCisplatinCombined Modality TherapyEtoposideFatal OutcomeFemaleHumansMagnetic Resonance ImagingNeoplasm Recurrence, LocalPositron-Emission TomographyVentriculoperitoneal ShuntAntineoplastic AgentsCisplatinEtoposideCNS Cancerneuroendocrinologyneurooncology

Identifiers

PMID31537610
PMCPMC6754666

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.