Evidence map›Paper›PMID 31537532›Full record

ArticleDisease models & mechanisms2019

Fetal exposure to maternal inflammation interrupts murine intestinal development and increases susceptibility to neonatal intestinal injury.

Timothy G Elgin, Erin M Fricke, Huiyu Gong, Jeffrey Reese, David A Mills, Karen M Kalantera, Mark A Underwood, Steven J McElroy

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Paneth cell ontogeny in term and preterm ovine models.Frontiers in veterinary science · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Molecular Mechanisms of Hyperoxia-Induced Neonatal Intestinal Injury.International journal of molecular sciences · 2023
    Review
  11. State-of-the-art review and update ofFrontiers in pediatrics · 2023
    Review
  12. Review
  13. LPS versus Poly I:C model: comparison of long-term effects of bacterial and viral maternal immune activation on the offspring.American journal of physiology. Regulatory, integrative and comparative physiology · 2022
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. COVID-19 in pregnancy: Placental and neonatal involvement.American journal of reproductive immunology (New York, N.Y. : 1989) · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Timothy G ElginDepartment of Pediatrics, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0001-5936-0463
Erin M FrickeDepartment of Obstetrics and Gynecology, University of Iowa, Iowa City, IA 52242, USA.
Huiyu GongDepartment of Pediatrics, University of Iowa, Iowa City, IA 52242, USA.
Jeffrey ReeseDepartment of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0001-8751-6146
David A MillsDepartment of Food Science and Technology, University of California Davis, Davis, CA 95616, USA.
Karen M KalanteraDepartment of Food Science and Technology, University of California Davis, Davis, CA 95616, USA.
Mark A UnderwoodDepartment of Pediatrics, University of California Davis, Sacramento, CA 95817, USA.ORCID 0000-0001-7453-5022
Steven J McElroyDepartment of Pediatrics, University of Iowa, Iowa City, IA 52242, USA Steven-mcelroy@uiowa.edu.ORCID 0000-0002-4321-723X
University of Iowa · USUniversity of California, Davis · USVanderbilt University · US

Funding

Detecting biochemical changes in the pregnant mouse cervix by Raman spectroscopyR01HD081121 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MAHADEVAN-JANSEN, ANITA, REESE, JOHN JEFFREY · 2014 to 2018
$1.9M
Role of Paneth Cells in Development of Necrotizing EnterocolitisR03DK097335 · NIDDK · UNIVERSITY OF IOWA · PI MCELROY, STEVEN JAMES · 2013 to 2014
$151k
NICHD NIH HHS R01 HD081121NIDDK NIH HHS R03 DK097335
6 · The paper itself

Abstract

Fetal exposure to chorioamnionitis can impact the outcomes of the developing fetus both at the time of birth and in the subsequent neonatal period. Infants exposed to chorioamnionitis have a higher incidence of gastrointestinal (GI) pathology, including necrotizing enterocolitis (NEC); however, the mechanism remains undefined. To simulate the fetal exposure to maternal inflammation (FEMI) induced by chorioamnionitis, pregnant mice (C57BL/6J,

Indexed as

AnimalsAnimals, NewbornBiomarkersCecumCytokinesDisease SusceptibilityFemaleFetusGoblet CellsInflammationIntestine, SmallLipopolysaccharidesMice, Inbred C57BLMicrobiotaPaneth CellsPregnancyBiomarkersCytokinesLipopolysaccharidesChorioamnionitisGobletIL-6LPSPaneth

Identifiers

PMID31537532
PMCPMC6826024
OpenAlexW2974767470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.