ArticleBlood2019
The architecture of the IgG anti-carbohydrate repertoire in primary antibody deficiencies.
Article in Blood, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Using Synthetic Glycans to Investigate Anti-Glycan Antibodies and Explore Their Medical Potential.Angewandte Chemie (International ed. in English) · 2026Review
- Point-of-care GlycoStrips detect serum and salivary antibodies to blood group antigens and pathogens.Trends in biotechnology · 2026Article
- Novel Click Coupling Chemistry to Explore Glycan Recognition.ACS central science · 2025Article
- Levels of Natural Antibodies Before and After Immunoglobulin Replacement Treatment Affect the Clinical Phenotype in Common Variable Immunodeficiency.Journal of clinical immunology · 2024Article
- Article
- Serum antibody screening using glycan arrays.Chemical Society reviews · 2024Review
- Antibody diversity in IVIG: Therapeutic opportunities for novel immunotherapeutic drugs.Frontiers in immunology · 2023Review
- Prognostic value of PD-L1 and Siglec-15 expression in patients with nasopharyngeal carcinoma.Scientific reports · 2022Article
- Diagnostic Vaccination in Clinical Practice.Frontiers in immunology · 2021Article
- Glycosylation and Cardiovascular Diseases.Advances in experimental medicine and biology · 2021Article
- Unique repertoire of anti-carbohydrate antibodies in individual human serum.Scientific reports · 2020Article
- Expression signature, prognosis value, and immune characteristics of Siglec-15 identified by pan-cancer analysis.Oncoimmunology · 2020Article
- Xenogeneic Neu5Gc and self-glycan Neu5Ac epitopes are potential immune targets in MS.Neurology(R) neuroimmunology & neuroinflammation · 2020Article
- Enhanced Pro-apoptotic Effects of Fe(II)-Modified IVIG on Human Neutrophils.Frontiers in immunology · 2020Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Immune system failure in primary antibody deficiencies (PADs) has been linked to recurrent infections, autoimmunity, and cancer, yet clinical judgment is often based on the reactivity to a restricted panel of antigens. Previously, we demonstrated that the human repertoire of carbohydrate-specific immunoglobulin G (IgG) exhibits modular organization related to glycan epitope structure. The current study compares the glycan-specific IgG repertoires between different PAD entities. Distinct repertoire profiles with extensive qualitative glycan-recognition defects were observed, which are characterized by the common loss of Galα and GalNAc reactivity and disease-specific recognition of microbial antigens, self-antigens, and tumor-associated carbohydrate antigens. Antibody repertoire analysis may provide a useful tool to elucidate the degree and the clinical implications of immune system failure in individual patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.