ArticleJournal of diabetes and its complications2019
Antidiabetic medication use in patients with type 2 diabetes and chronic kidney disease.
Article in Journal of diabetes and its complications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Metformin-Associated Encephalopathy as a Rare but Serious Adverse Effect: A Case Report.Cureus · 2026Article
- Impact of Improved Diagnosis and Treatment on Holistic CKD Burden.Kidney international reports · 2025Article
- Trends in Antidiabetic Drug Use and Safety of Metformin in Diabetic Patients with Varying Degrees of Chronic Kidney Disease from 2010 to 2021 in Korea: Retrospective Cohort Study Using the Common Data Model.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Optimising antidiabetic medication management for type 2 diabetes and renal dysfunction in Can Tho City, Vietnam.Przeglad menopauzalny = Menopause review · 2024Article
- Severity and Duration of Acute Kidney Injury and Chronic Kidney Disease after Cardiac Surgery.Journal of clinical medicine · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
aimsTo quantify patterns of conventional and newer antidiabetic medication use in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD).
methodsWe used data from a large claims and integrated dataset that includes employed and commercially insured patients in the US to select patients who had T2DM and CKD with information on laboratory values and prescriptions for antidiabetic medications from January 1, 2014 to January 1, 2015. We stratified the analyses by sociodemographic variables.
resultsIn a cohort of 38,577 patients with T2DM and CKD, we found wide variation in the treatment of T2DM by CKD stage as well as by several sociodemographic factors. Although metformin was the most commonly prescribed medication, only about half of patients in the cohort and fewer than two-thirds of patients with early stage CKD were prescribed metformin. Approximately 10.6% of patients with CKD stage 4 and 2.1% of the patients with CKD stage 5 were prescribed metformin. Sulfonylureas with active metabolites that accumulate with impaired kidney function were prescribed in more than one-third of patients with CKD stages 3b, 4, and 5. Only 3.4% and 12.3% of patients were prescribed GLP-1 and DPP-4 respectively.
conclusionsPrescriptions for metformin were lower than expected among patients with mild to moderate CKD. Prescriptions for newer antidiabetic medications with known safety and efficacy across the spectrum of CKD remained low. Prescriptions for agents contraindicated in advanced CKD continued to be written in a sizeable fraction of patients.
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