ArticleJournal of the American College of Cardiology2019
2-Year Outcomes After Complete or Staged Procedure for Tetralogy of Fallot in Neonates.
Article in Journal of the American College of Cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Outcomes of Primary Vs. Staged Repair in 4628 Neonates with Symptomatic Tetralogy of Fallot: A Systematic Review and Meta-analysis.Pediatric cardiology · 2026Pooled it
- Managing cyanotic neonates with tetralogy of Fallot: A national perspective on surgical approaches.JTCVS open · 2026Article
- Adapting to Constraints: Successful Repair of a Challenging Tetralogy of Fallot Case.Case reports in pediatrics · 2026Article
- Timing and Mode of Death Following Treatment of Neonatal Symptomatic Tetralogy of Fallot.Journal of the American Heart Association · 2025Article
- Optimal Management of the Cyanotic Neonate With Tetralogy of Fallot-A Clinical Decision Analysis.Annals of thoracic surgery short reports · 2025Article
- Article
- The Association of Gestational Age and Size with Management Strategies and Outcomes in Symptomatic Neonatal Tetralogy of Fallot.Pediatric cardiology · 2024Article
- Neurodevelopment in patients with repaired tetralogy of Fallot.Frontiers in pediatrics · 2024Review
- Trends in Ductus Arteriosus Stent Versus Blalock-Taussig-Thomas Shunt Use and Comparison of Cost, Length of Stay, and Short-Term Outcomes in Neonates With Ductal-Dependent Pulmonary Blood Flow: An Observational Study Using the Pediatric Health Information Systems Database.Journal of the American Heart Association · 2023Observational
- Optimal Surgical Management of Tetralogy of Fallot.CJC pediatric and congenital heart disease · 2023Review
- Considerations in Timing of Surgical Repair in Tetralogy of Fallot.CJC pediatric and congenital heart disease · 2023Review
- Biomarkers, Socioeconomic Factors, and Right Ventricular Function After Surgical Repair for Tetralogy of Fallot.Pediatric cardiology · 2023Article
- Right Ventricular Strain in Patients With Ductal-Dependent Tetralogy of Fallot.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2023Article
- Leveraging machine learning to identify acute myeloid leukemia patients and their chemotherapy regimens in an administrative database.Pediatric blood & cancer · 2023Article
- Short-Term Outcomes of Epidural Analgesia in Minimally Invasive Esophagectomy for Esophageal Cancer: Nationwide Inpatient Data Study in Japan.Annals of surgical oncology · 2022Article
- Palliation Strategy to Achieve Complete Repair in Symptomatic Neonates with Tetralogy of Fallot.Pediatric cardiology · 2022Article
- Prognostic Value of Preoperative Absolute Lymphocyte Count in Children With Tetralogy of Fallot.Journal of the American Heart Association · 2021Observational
- Identifying Risk Factors for Complicated Post-operative Course in Tetralogy of Fallot Using a Machine Learning Approach.Frontiers in cardiovascular medicine · 2021Article
- Association of Pulmonary Valve Morphology Differences With Outcomes in Tetralogy of Fallot Repair With Right Ventricular Outflow Tract Incision.Frontiers in cardiovascular medicine · 2021Article
- Resource Utilization in the First 2 Years Following Operative Correction for Tetralogy of Fallot: Study Using Data From the Optum's De-Identified Clinformatics Data Mart Insurance Claims Database.Journal of the American Heart Association · 2020Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThere is ongoing debate about the best strategy to treat patients with tetralogy of Fallot who are symptomatic in the neonatal period.
objectivesThe aim of this study was to compare the outcomes of complete versus staged surgery (i.e., initial palliative procedure for possible later complete repair).
methodsA retrospective cohort study was performed using the Pediatric Health Information System database, including patients who underwent complete or staged tetralogy of Fallot repair prior to 30 days of age. The primary outcome was death during 2-year follow-up after the initial procedure. Inverse probability-weighted Cox and logistic regression models were used to examine the association between surgical approach group and mortality while accounting for patient- and hospital-level factors. Causal mediation analyses examined the role of intermediate variables.
resultsA total of 2,363 patients were included (1,032 complete and 1,331 staged). There were 239 deaths. Complete neonatal repair was associated with a significantly higher risk for mortality during the 2-year follow-up period (hazard ratio: 1.51; 95% confidence interval: 1.05 to 2.06), between 7 and 30 days after the initial procedure (hazard ratio: 2.29; 95% confidence interval: 1.18 to 4.41), and during the initial hospital admission (odds ratio: 1.72; 95% confidence interval: 1.15 to 2.62). Post-operative cardiac complications were more common in the complete repair group and mediated the differences in 30-day and 2-year mortality.
conclusionsComplete surgical repair for neonates with tetralogy of Fallot is associated with a significantly higher risk for early and 2-year mortality compared with the staged approach, after accounting for patient and hospital characteristics. Post-operative cardiac complications mediated these findings.
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