ReviewThe American journal of psychiatry2020
The Devastating Clinical Consequences of Child Abuse and Neglect: Increased Disease Vulnerability and Poor Treatment Response in Mood Disorders.
Review in The American journal of psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 196 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
196 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effectiveness of Attachment-Based Interventions for Maltreated Children's Well-Being: A Systematic Review.Clinical child and family psychology review · 2026Pooled it
- A Systematic Review and Meta-Analysis of the Association Between Childhood Maltreatment and Adult Depression.Acta psychiatrica Scandinavica · 2025Pooled it
- Pooled it
- Effects of parent-child interaction therapy dosage on child and parent outcomes: differentiating child-directed interaction and parent-directed interaction session impacts in child welfare-involved families.Journal of child psychology and psychiatry, and allied disciplines · 2026Trial
- S-adenosylmethionine as an epigenetic treatment of depression in adults with childhood trauma.Epigenomics · 2026Trial
- The Differential Relation of Emotional, Physical, and Sexual Abuse Histories to Antidepressant Treatment Remission and Persistence of Anhedonia in Major Depression: A CAN-BIND-1 Report.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2023Trial
- Subjective response to alcohol: Interactive effects of early life stress, parental risk for mood and substance use disorders, and drinking context.Pharmacology, biochemistry, and behavior · 2023Trial
- Randomized trial of promoting first relationships for new mothers who received community mental health services in pregnancy.Developmental psychology · 2021Trial
- Effectiveness of Collaborative, Trauma-Informed Care on Depression Outcomes in Primary Care: A Cluster Randomized Control Trial in Chile.Annals of family medicineTrial
- Identifying differential interactions of potentially traumatic experiences with genetic risk for posttraumatic stress disorder.European journal of psychotraumatology · 2026Article
- Impact of Adverse Childhood Experiences (ACEs) on Mental Health Help-Seeking Among Asian American Adults: Findings from the 2021 California Health Interview Survey.Journal of immigrant and minority health · 2026Article
- A Digital Registry and Education Network for Child Maltreatment Protection: Protocol for a Pilot Observational Exploratory Intervention Study.JMIR research protocols · 2026Observational
- Disseminating brief video-based mental health interventions on Instagram: Reach, engagement, and real-world implementation.Internet interventions · 2026Article
- A systematic review and meta-analysis examining the impact of placement instability on the mental health outcomes of care experienced children and young people.JCPP advances · 2026Article
- Article
- Reimagining the Biopsychosocial Model: Transdiagnostic Factors to Precision Psychiatry.Biological psychiatry global open science · 2026Article
- Psychiatric nurses' clinical decision-making for adults clinically judged to have childhood maltreatment-related attachment difficulties: A qualitative study employing the steps for coding and theorization method.Japan journal of nursing science : JJNS · 2026Article
- Substance use and mental health outcomes in children and adolescents exposed to household dysfunction: mediating role of emotional intelligence.BJPsych open · 2026Article
- Using Digital Mental Health and Measurement-Based Care With Youth Experiencing Suicidal Thoughts and Behaviors: Qualitative Study of Clinician Barriers and Facilitators.JMIR human factors · 2026Article
- Subcortical brain structures among maltreated youth with high and low externalizing problems.European child & adolescent psychiatry · 2026Article
136 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors.
Funding
Abstract
A large body of evidence has demonstrated that exposure to childhood maltreatment at any stage of development can have long-lasting consequences. It is associated with a marked increase in risk for psychiatric and medical disorders. This review summarizes the literature investigating the effects of childhood maltreatment on disease vulnerability for mood disorders, specifically summarizing cross-sectional and more recent longitudinal studies demonstrating that childhood maltreatment is more prevalent and is associated with increased risk for first mood episode, episode recurrence, greater comorbidities, and increased risk for suicidal ideation and attempts in individuals with mood disorders. It summarizes the persistent alterations associated with childhood maltreatment, including alterations in the hypothalamic-pituitary-adrenal axis and inflammatory cytokines, which may contribute to disease vulnerability and a more pernicious disease course. The authors discuss several candidate genes and environmental factors (for example, substance use) that may alter disease vulnerability and illness course and neurobiological associations that may mediate these relationships following childhood maltreatment. Studies provide insight into modifiable mechanisms and provide direction to improve both treatment and prevention strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.