ArticleKidney research and clinical practice2019
Serum myostatin levels are associated with abdominal aortic calcification in dialysis patients.
Article in Kidney research and clinical practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Trial
- The serum levels of gasdermin D in uremic patients and its relationship with the prognosis: a prospective observational cohort study.Renal failure · 2024Observational
- Observational
- Serum Myostatin at Dialysis Initiation May Predict 1-Year Mortality and Hospitalization.Nephron · 2024Article
- Sarcopenia and cardiovascular disease in patients with and without kidney disease: what do we know?International urology and nephrology · 2023Review
- Omega-3 fatty acid and menaquinone-7 combination are helpful for aortic calcification prevention, reducing osteoclast area of bone and Fox0 expression of muscle in uremic rats.Renal failure · 2022Article
- The Correlation of Serum Myostatin Levels with Gait Speed in Kidney Transplantation Recipients.International journal of environmental research and public health · 2022Article
- Vascular Calcification in Chronic Kidney Disease: Distinct Features of Pathogenesis and Clinical Implication.Korean circulation journal · 2021Review
- Low Muscle Mass in Patients Receiving Hemodialysis: Correlations with Vascular Calcification and Vascular Access Failure.Journal of clinical medicine · 2021Article
- Review
- Myostatin/Appendicular Skeletal Muscle Mass (ASM) Ratio, Not Myostatin, Is Associated with Low Handgrip Strength in Community-Dwelling Older Women.International journal of environmental research and public health · 2021Article
- Serum uric acid is associated with coronary artery calcification in early chronic kidney disease: a cross-sectional study.BMC nephrology · 2021Article
- Myostatin: The Missing Link between Sarcopenia and Cardiovascular Disease in Chronic Kidney Disease?Journal of atherosclerosis and thrombosis · 2020Article
- Activin/myostatin receptor signaling and vascular calcifications in chronic kidney disease: A "liaison dangereuse"?Kidney research and clinical practice · 2019Article
- Serum myostatin level is a positive predictor of endothelial function measured by digital thermal monitoring of vascular reactivity in kidney transplantation patients.Tzu chi medical journalArticle
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSerum myostatin levels are increased according to renal function decline and myostatin may be a main mediator of chronic kidney disease-related sarcopenia. A previous study reported that serum myostatin level was negatively associated with abdominal aortic calcification (AAC) in older males. The aim of this study was to assess the association between serum myostatin level and AAC among dialysis patients of both sexes. In addition, we analyzed the relationship between serum myostatin level, muscle mass, and bone mineral density (BMD).
methodsIn this cross-sectional study, we evaluated AAC in the lateral lumbar spine using plain radiography and BMD in 71 patients undergoing dialysis. We classified patients into two groups according to the median value of myostatin as follows: those with high myostatin levels (≥ 5.0 ng/mL) and those with low myostatin levels (< 5.0 ng/mL).
resultsThe proportion of patients with an AAC score of five points or more was higher among those with low myostatin levels. Myostatin level was negatively associated with AAC scores on plain radiography and had a positive association with skeletal muscle mass and T-scores for BMD measured at the total hip and femur neck. Lower myostatin levels were independently associated with higher AAC scores following adjustment for age, sex, diabetes mellitus, dialysis vintage, dialysis modality, and osteoprotegerin level.
conclusionLower serum myostatin levels were associated with higher AAC scores, lower muscle mass, and lower BMD in dialysis patients. Further, prospective studies and those with larger cohorts are necessary to validate these findings.
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