ArticlePediatric research2020
The impact of fluid balance on outcomes in premature neonates: a report from the AWAKEN study group.
Article in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02443389 (Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates), which is not on this map. Cited by 48 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates
Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Acute kidney injury magnitude, mortality, and associated factors among neonates in sub-Saharan Africa: a systematic review and meta-analysis.Pediatric nephrology (Berlin, Germany) · 2025Pooled it
- Association between fluid overload and mortality in newborns: a systematic review and meta-analysis.Pediatric nephrology (Berlin, Germany) · 2022Pooled it
- Elevated serum creatinine over the first week of life and mortality risk in extremely preterm neonates: a secondary analysis of the Preterm Erythropoietin Neuroprotection Trial (PENUT).Pediatric nephrology (Berlin, Germany) · 2026Trial
- Acute Kidney Injury Defined by Fluid-Corrected Creatinine in Premature Neonates: A Secondary Analysis of the PENUT Randomized Clinical Trial.JAMA network open · 2023Trial
- Association of Fluid Balance With Short- and Long-term Respiratory Outcomes in Extremely Premature Neonates: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2022Trial
- Early fluid status and severe intraventricular hemorrhage or death in extremely preterm infants.Pediatric nephrology (Berlin, Germany) · 2026Article
- Weight changes and variability in the first week of life: associations with mortality in extremely preterm newborns.Pediatric nephrology (Berlin, Germany) · 2026Article
- A Pathophysiological Approach for Early Detection and Prevention of AKI in the NICU.American journal of perinatology · 2026Review
- Food for thought: a mixed methods analysis of nutrition decision making during bedside rounds in the neonatal intensive care unit.Pediatric research · 2026Article
- Neonatal Acute Kidney Injury-An Australian and New Zealand Perspective.Journal of paediatrics and child health · 2026Review
- Continuous kidney replacement therapy with CARPEDIEMPediatric nephrology (Berlin, Germany) · 2026Article
- Association between weight changes the first postnatal week and bronchopulmonary dysplasia-free survival in infants born at 23-26 weeks of gestation.European journal of pediatrics · 2026Observational
- Acute kidney injury in extremely preterm infants: findings from an Australian single-centre retrospective cohort study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Speed of intravenous fluid on glycocalyx integrity and central blood volume in a porcine septic shock model.Intensive care medicine experimental · 2026Article
- [Association between early fluid overload and critical complications in extremely low birth weight infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- High early fluid and sodium intake as risk factors for acute kidney injury in very-low-birthweight infants.Pediatric nephrology (Berlin, Germany) · 2026Article
- Neonatal acute kidney injury: a survey of practices in Canadian neonatal intensive care units.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Reducing NICU ventilator days by preventing fluid overload with the CAN-U-P-LOTS standardized bundle.Pediatric research · 2026Article
- Lung ultrasound score and left ventricular eccentricity index in preterm infants with respiratory failure - a pilot study.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Neonatal Kidney Function, Injury and Drug Dosing: A Contemporary Review.Children (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
19 authors at 20 institutions in 4 countries.
Funding
Abstract
backgroundWe evaluated the epidemiology of fluid balance (FB) over the first postnatal week and its impact on outcomes in a multi-center cohort of premature neonates from the AWAKEN study.
methodsRetrospective analysis of infants <36 weeks' gestational age from the AWAKEN study (N = 1007). FB was defined by percentage of change from birth weight. OUTCOME: Mechanical ventilation (MV) at postnatal day 7.
resultsOne hundred and forty-nine (14.8%) were on MV at postnatal day 7. The median peak FB was 0% (IQR: -2.9, 2) and occurred on postnatal day 2 (IQR: 1,5). Multivariable models showed that the peak FB (aOR 1.14, 95% CI 1.10-1.19), lowest FB in first postnatal week (aOR 1.12, 95% CI 1.07-1.16), and FB on postnatal day 7 (aOR 1.10, 95% CI 1.06-1.13) were independently associated with MV on postnatal day 7. In a similar analysis, a negative FB at postnatal day 7 protected against the need for MV at postnatal day 7 (aOR 0.21, 95% CI 0.12-0.35).
conclusionsPositive peak FB during the first postnatal week and more positive FB on postnatal day 7 were independently associated with MV at postnatal day 7. Those with a negative FB at postnatal day 7 were less likely to require MV.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.