Evidence map›Paper›PMID 31536744›Full record

ArticleJournal of molecular and cellular cardiology2019

A knock-in mutation at cysteine 144 of TRIM72 is cardioprotective and reduces myocardial TRIM72 release.

Natasha Fillmore, Kevin M Casin, Prithvi Sinha, Junhui Sun, Hanley Ma, Jennifer Boylston, Audrey Noguchi, Chengyu Liu, Nadan Wang, Guangshuo Zhou and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. GSNOR deletion differentially alters age-related cardiac function in a sex-dependent manner.American journal of physiology. Heart and circulatory physiology · 2026
    Article
  5. Review
  6. Blocking MG53Circulation research · 2022
    Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Natasha FillmoreLaboratory of Cardiac Physiology, NHLBI, NIH, Bethesda, MD, United States of America.
Kevin M CasinDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America.
Prithvi SinhaDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America.
Junhui SunLaboratory of Cardiac Physiology, NHLBI, NIH, Bethesda, MD, United States of America.
Hanley MaLaboratory of Cardiac Physiology, NHLBI, NIH, Bethesda, MD, United States of America.
Jennifer BoylstonLaboratory of Cardiac Physiology, NHLBI, NIH, Bethesda, MD, United States of America.
Audrey NoguchiMurine Phenotyping Core, NHLBI, NIH, Bethesda, MD, United States of America.
Chengyu LiuTransgenic Core, NHLBI, NIH, Bethesda, MD, United States of America.
Nadan WangCardiovascular Physiology and Surgery Core, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
Guangshuo ZhouCardiovascular Physiology and Surgery Core, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
Mark J KohrDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America. Electronic address: mkohr1@jhu.edu.
Elizabeth MurphyLaboratory of Cardiac Physiology, NHLBI, NIH, Bethesda, MD, United States of America. Electronic address: murphy1@mail.nih.gov.
Johns Hopkins University · USNational Institutes of Health · USNational Heart Lung and Blood Institute · US

Funding

Traning Program in Environmental Health SciencesT32ES007141 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI Marsha Wills-Karp · 1985 to 2026
$22.2M
Mechanisms of cardiac ischemia-reperfusion injury and cardioprotectionZIAHL002066 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI MURPHY, ELIZABETH · 2009 to 2025
$20.4M
Role of S-nitrosylation in regulating cardiac function and diseaseZIAHL006059 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI MURPHY, ELIZABETH · 2010 to 2025
$7.2M
S-nitrosation in cell survival and cell deathR01HL136496 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KOHR, MARK JEFFREY · 2018 to 2022
$2.0M
Mechanisms of cardiac ischemia-reperfusion injury and cardioprotectionZ01HL002066 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI MURPHY, ELIZABETH · 2008 to 2008
$607k
Intramural NIH HHS Z01 HL002066Intramural NIH HHS ZIA HL002066Intramural NIH HHS ZIA HL006059NHLBI NIH HHS R01 HL136496NIEHS NIH HHS T32 ES007141
6 · The paper itself

Abstract

TRIM72 is a membrane repair protein that protects against ischemia reperfusion (I/R) injury. We previously identified Cys

Indexed as

MutationAngiotensin IIAnimalsCardiomegalyCoronary Artery DiseaseCysteineDisease Models, AnimalGene Knock-In TechniquesInsulin ResistanceMembrane ProteinsMice, Inbred C57BLMice, Mutant StrainsMyocardial Reperfusion InjuryMyocardiumAngiotensin IICysteineMembrane ProteinsMG53 protein, mouse

Identifiers

PMID31536744
PMCPMC7000244
OpenAlexW2974291124

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.