ArticlePloS one2019
The impact of admission serum lactate on children with moderate to severe traumatic brain injury.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 43 citations in OpenAlex.
- Lactate-albumin ratio measurements at multiple time points and their association with outcome in pediatric trauma: a PICU-based study.BMC pediatrics · 2026Observational
- Development of a prediction model for mortality in infants undergoing therapeutic hypothermia for neonatal encephalopathy.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Early lactate elimination trend during therapeutic hypothermia predicts acute kidney injury in hypoxic ischemic encephalopathy.Pediatric nephrology (Berlin, Germany) · 2026Article
- Article
- Time-weighted lactate and glucose-lactate ratio outperform static values in ICU mortality prediction after traumatic brain injury: a retrospective cohort study.Journal of intensive care · 2026Article
- Development and validation of a clinical nomogram for predicting 30-day in-hospital mortality in children with moderate-to-severe traumatic brain injury.Frontiers in pediatrics · 2026Article
- Interpretable Multiomics Models for Predicting Surgical Interventions and Blood Transfusion Requirements in Traumatic Brain Injury.NPJ digital medicine · 2025Article
- Article
- Results of therapy in children diagnosed with severe traumatic brain injury.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Lactate Levels in a Replanted Limb as an Early Biomarker for Assessing Post-Surgical Evolution: A Case Report.Diagnostics (Basel, Switzerland) · 2025Article
- The significance of admission blood lactate and fibrinogen in pediatric traumatic brain injury: a single-center clinical study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Thiamine use is associated with better outcomes for traumatic brain injury patients.Frontiers in nutrition · 2024Article
- The lactate-to-albumin ratio relationship with all-cause mortality in cerebral infarction patients: analysis from the MIMIC-IV database.Frontiers in neurology · 2024Article
- Association of initial assessment variables and mortality in severe pediatric traumatic brain injury.World journal of pediatric surgery · 2024Article
- Article
- The association between lactate to albumin ratio and outcomes at early phase in patients with traumatic brain injury.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2023Observational
- Insights into Hemodynamic Features of Survivors and the Deceased with Acute Brain Injury: A Step Forward Tailored Treatment.Journal of clinical medicine · 2023Article
- Impact of Serum Lactate as an Early Serum Biomarker for Cardiopulmonary Parameters within the First 24 Hours of Intensive Care Unit Treatment in Patients with Isolated Traumatic Brain Injury.Diagnostics (Basel, Switzerland) · 2023Article
- Early metabolic derangements and unfavorable outcomes in pediatric traumatic brain injury: a retrospective multi-center cohort study.Translational pediatrics · 2023Article
- Serum lactate monitoring may help to predict neurological function impairment caused by acute metabolism crisis.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLactate is used to evaluate the prognosis of adult patients with trauma. However, the prognostic significance of admission serum lactate in the setting of pediatric traumatic brain injury (TBI) is still unclear. We aim to investigate the impact of admission lactate on the outcome in children with moderate to severe TBI.
methodsThis retrospective study was conducted in a tertiary pediatric hospital between May 2012 and Jun 2018 included children with an admission Glasgow Coma Scale (GCS) of ≤13. Two hundred and thirteen patients were included in the analysis and 45 patients died in hospital.
resultsAdmission lactate and glucose were significantly higher in non-survivors than those in survivors (P < 0.05). Admission lactate was positively correlated with admission glucose and negatively correlated with GCS in all patients (n = 213), subgroup of isolated TBI (n = 112) and subgroup of GCS ≤ 8 (n = 133), respectively. AUCs of lactate could significantly predict the mortality and were higher than those of glucose in all patients, subgroup of isolated TBI and subgroup of GCS ≤ 8, respectively. Multivariate logistic regression showed that admission lactate (Adjusted OR = 1.189; 95% CI: 1.002-1.410; P = 0.047) was independently associated with mortality, while admission glucose (Adjusted OR = 1.077; 95% CI: 0.978-1.186; P = 0.133) wasn't an independent risk factor of death. Elevated admission lactate (> 2 mmol/L) was associated with death, reduced 14-day ventilation-free days, 14-day ICU-free days and 28-day hospital-free days.
conclusionsAdmission serum lactate can effectively predict the mortality of children with moderate to severe TBI. Elevated admission lactate is associated with death, reduced ventilator-free, ICU-free, and hospital-free days. Admission serum lactate could be used as a prognostic biomarker of mortality in children with moderate to severe TBI.
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