ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2020
The "central vein sign" in patients with diagnostic "red flags" for multiple sclerosis: A prospective multicenter 3T study.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Central Vein Sign Profile of Newly Developing Lesions in Multiple Sclerosis: A 3-Year Longitudinal Study.Neurology(R) neuroimmunology & neuroinflammation · 2022Trial
- Complex Deep Neural Networks for Denoising Ultra-Fast Submillimeter T2*-weighted Imaging and Quantitative Susceptibility Mapping.European journal of radiology artificial intelligence · 2026Article
- The Kappa Free Light Chains Index and Central Vein Sign: Two New Biomarkers for Multiple Sclerosis Diagnosis.Neurology and therapy · 2025Review
- Diagnostic performance of central vein sign versus oligoclonal bands for multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024Article
- New Imaging Markers in Multiple Sclerosis and Related Disorders: Smoldering Inflammation and the Central Vein Sign.Neuroimaging clinics of North America · 2024Review
- Central Vein Sign, Cortical Lesions, and Paramagnetic Rim Lesions for the Diagnostic and Prognostic Workup of Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2024Observational
- Central Vein Sign and Paramagnetic Rim Lesions: Susceptibility Changes in Brain Tissues and Their Implications for the Study of Multiple Sclerosis Pathology.Diagnostics (Basel, Switzerland) · 2024Review
- Identification and management of subclinical disease activity in early multiple sclerosis: a review.Journal of neurology · 2024Review
- The diagnostic value of the central vein sign in radiologically isolated syndrome.Annals of clinical and translational neurology · 2024Article
- Central intra-lesional iron deposits as a possible novel imaging marker at 7 Tesla MRI in Susac Syndrome - an exploratory study.BMC medical imaging · 2024Article
- A multicenter pilot study evaluating simplified central vein assessment for the diagnosis of multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024Article
- Is the central vein sign a useful diagnostic marker for paediatric-onset multiple sclerosis?Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Multiple Sclerosis in a Patient With Neurogenic Locus Notch Homolog Protein 3 Mutation.Journal of clinical neurology (Seoul, Korea) · 2023Article
- Supporting the differential diagnosis of connective tissue diseases with neurological involvement by blood and cerebrospinal fluid flow cytometry.Journal of neuroinflammation · 2023Article
- Central vein sign and diffusion MRI differentiate microstructural features within white matter lesions of multiple sclerosis patients with comorbidities.Frontiers in neurology · 2023Article
- Neurodegeneration in multiple sclerosis.WIREs mechanisms of disease · 2023Review
- Central vein sign: comparison of multiple sclerosis and leukoaraiosis.Turkish journal of medical sciences · 2022Article
- Neuroradiological differentiation of white matter lesions in patients with multiple sclerosis and Fabry disease.Orphanet journal of rare diseases · 2022Article
- Cognitive impairment, the central vein sign, and paramagnetic rim lesions in RIS.Multiple sclerosis (Houndmills, Basingstoke, England) · 2021Article
- Challenging Mimickers in the Diagnosis of Sarcoidosis: A Case Study.Diagnostics (Basel, Switzerland) · 2021Article
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Funding
Abstract
backgroundThe central vein sign (CVS) has been shown to help in the differential diagnosis of multiple sclerosis (MS), but most prior studies are retrospective.
objectivesTo prospectively assess the diagnostic predictive value of the CVS in diagnostically difficult cases.
methodsIn this prospective multicenter study, 51 patients with suspected MS who had clinical, imaging, or laboratory "red flags" (i.e. features atypical for MS) underwent 3T fluid-attenuated inversion recovery (FLAIR*) magnetic resonance imaging (MRI) for CVS assessment. After the diagnostic work-up, expert clinicians blinded to the results of the CVS assessment came to a clinical diagnosis. The value of the CVS to prospectively predict an MS diagnosis was assessed.
resultsOf the 39 patients who received a clinical diagnosis by the end of the study, 27 had MS and 12 received a non-MS diagnosis that included systemic lupus erythematosus, sarcoidosis, migraine, Sjögren disease, SPG4-spastic-paraparesis, neuromyelitis optica, and Susac syndrome. The percentage of perivenular lesions was higher in MS (median = 86%) compared to non-MS (median = 21%;
conclusionThe CVS detected on 3T FLAIR* images can accurately predict an MS diagnosis in patients suspected to have MS, but with atypical clinical, laboratory, and imaging features.
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