ArticleInfluenza and other respiratory viruses2019
Nosocomial transmission of influenza: A retrospective cross-sectional study using next generation sequencing at a hospital in England (2012-2014).
Article in Influenza and other respiratory viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- [Understanding vaccination behavior of healthcare workers in German hospitals-results from the OKaPII study].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2025Article
- Nanopore sequencing of influenza A and B in Oxfordshire and the United Kingdom, 2022-23.The Journal of infection · 2024Article
- Vaccine mandates for healthcare workers beyond COVID-19.Journal of medical ethics · 2023Article
- Investigating Epidemiologic and Molecular Links Between Patients With Community- and Hospital-Acquired Influenza A: 2017-2018 and 2019-2020, Michigan.Open forum infectious diseases · 2023Article
- Genomic Epidemiology and Transmission Dynamics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Congregate Healthcare Facilities in Santa Clara County, California.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Methods Combining Genomic and Epidemiological Data in the Reconstruction of Transmission Trees: A Systematic Review.Pathogens (Basel, Switzerland) · 2022Review
- Real-Time Investigation of a Large Nosocomial Influenza A Outbreak Informed by Genomic Epidemiology.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Use of point-of-care testing for respiratory viruses in hospital.The Lancet. Respiratory medicine · 2021Article
- Point of care testing of Influenza A/B and RSV in an adult respiratory assessment unit is associated with improvement in isolation practices and reduction in hospital length of stay.Journal of medical microbiology · 2020Article
- Nosocomial transmission of influenza: A retrospective cross-sectional study using next generation sequencing at a hospital in England (2012-2014).Influenza and other respiratory viruses · 2019Article
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17 authors.
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Abstract
backgroundThe extent of transmission of influenza in hospital settings is poorly understood. Next generation sequencing may improve this by providing information on the genetic relatedness of viral strains.
objectivesWe aimed to apply next generation sequencing to describe transmission in hospital and compare with methods based on routinely-collected data.
methodsAll influenza samples taken through routine care from patients at University College London Hospitals NHS Foundation Trust (September 2012 to March 2014) were included. We conducted Illumina sequencing and identified genetic clusters. We compared nosocomial transmission estimates defined using classical methods (based on time from admission to sample) and genetic clustering. We identified pairs of cases with space-time links and assessed genetic relatedness.
resultsWe sequenced influenza sampled from 214 patients. There were 180 unique genetic strains, 16 (8.8%) of which seeded a new transmission chain. Nosocomial transmission was indicated for 32 (15.0%) cases using the classical definition and 34 (15.8%) based on genetic clustering. Of the 50 patients in a genetic cluster, 11 (22.0%) had known space-time links with other cases in the same cluster. Genetic distances between pairs of cases with space-time links were lower than for pairs without spatial links (P < .001).
conclusionsGenetic data confirmed that nosocomial transmission contributes significantly to the hospital burden of influenza and elucidated transmission chains. Prospective next generation sequencing could support outbreak investigations and monitor the impact of infection and control measures.
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