Trial reportThe American journal of clinical nutrition2019
Optimizing the growth of very-low-birth-weight infants requires targeting both nutritional and nonnutritional modifiable factors specific to stage of hospitalization.
Trial report in The American journal of clinical nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Trial
- Association between postnatal anthropometric growth by term and high-performing neurodevelopment at age 3 years in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Nutrition of the preterm infant with persistent ductus arteriosus: existing evidence and practical implications.Pediatric research · 2026Review
- An investigation into the status of human milk feeding in very low birth weight infants: a multicenter study.International breastfeeding journal · 2026Observational
- Article
- Article
- Risk factors for intraventricular hemorrhage in very low birth weight infants: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Review
- Expected and Desirable Preterm and Small Infant Growth Patterns.Advances in nutrition (Bethesda, Md.) · 2024Review
- The Impact of Estimated Energy and Protein Balances on Extrauterine Growth in Preterm Infants.Nutrients · 2023Article
- Article
- Donor human milk processing and its impact on infant digestion: A systematic scoping review of in vitro and in vivo studies.Advances in nutrition (Bethesda, Md.) · 2023Article
- Effects of early intake of amino acid on the neurodevelopmental outcomes in very low birth weight infants at correct age of 20 months and school age.Irish journal of medical science · 2022Article
- Diet Quality and Cognitive Performance in Children Born Very Low Birth Weight.Frontiers in nutrition · 2022Article
- Postnatal growth and gut microbiota development influenced early childhood growth in preterm infants.Frontiers in pediatrics · 2022Article
- Social-Cognitive Network Connectivity in Preterm Children and Relations With Early Nutrition and Developmental Outcomes.Frontiers in systems neuroscience · 2022Article
- Determinants of fatty acid content and composition of human milk fed to infants born weighing <1250 g.The American journal of clinical nutrition · 2021Article
- Growth Failure Prevalence in Neonates with Gastroschisis : A Statewide Cohort Study.The Journal of pediatrics · 2021Article
- Early nutrition and white matter microstructure in children born very low birth weight.Brain communications · 2021Article
- A comparison of macronutrient-based methods for deriving energy values in human milk.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Protein Intakes during Weaning from Parenteral Nutrition Drive Growth Gain and Body Composition in Very Low Birth Weight Preterm Infants.Nutrients · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundData on how baseline characteristics, acuity, morbidity, and nutrition work in combination to affect the growth of very-low-birth-weight (VLBW, <1500 g) infants are limited.
objectiveWe aimed to determine factors associated with in-hospital weight, length, and head circumference (HC) trajectories of VLBW infants.
methodsVLBW infants (n = 316) from the GTA-DoMINO trial were included. Linear mixed-effects models assessed relations of baseline characteristics, acuity (at birth, across hospitalization), major morbidities, and nutrition (enteral feeding type, macronutrient/energy intakes) with changes in anthropometrics over hospitalization (days 1-8, 9-29, 30-75).
resultsSpecific factors and the strength of their associations with growth depended on in-hospital time interval. Small-for-gestational-age infants experienced weight gain (4.3 g · kg-1 · d-1; 95% CI: 2.0, 6.5 g · kg-1 · d-1) during days 1-8, versus weight loss (-4.6 g · kg-1 · d-1; 95% CI: -5.6, -3.7 g · kg-1 · d-1) among appropriate-for-gestational-age infants (P < 0.001). Positive-pressure ventilation (versus oxygen/room air) was associated with slower weight (-1.8 g · kg-1 · d-1) and HC (-0.25 cm/wk) gain during days 9-29 (P < 0.001). Morbidities were negatively associated with growth after days 1-8, with patent ductus arteriosus (PDA) showing negative associations with weight (-2.7 g · kg-1 · d-1), length (-0.11 cm/wk), and HC (-0.21 cm/wk) gain during days 9-29 (P < 0.001). Macronutrient/energy intakes were associated with weight across hospitalization (P ≤ 0.01), with greater weight gain (1.3-3.0 g · kg-1 · d-1) among infants achieving macronutrient/energy recommendations during days 9-29 and 30-75. Macronutrient/energy intakes were associated with HC during the first month (P = 0.013-0.003), with greater HC gain (0.07-0.12 cm/wk) among infants achieving protein, lipid, and energy recommendations during days 9-29.
conclusionsBaseline characteristics, acuity, morbidity, and nutrition factors were independently associated with VLBW infant growth. A focus on achieving macronutrient/energy recommendations and improving nutrient delivery to PDA-diagnosed infants may yield improvements to their growth. This trial was registered at www.isrctn.com as ISRCTN35317141.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.