Evidence map›Paper›PMID 31535846›Full record

ArticleBiomacromolecules2019

HPMA-Based Nanoparticles for Fast, Bioorthogonal iEDDA Ligation.

Stefan Kramer, Dennis Svatunek, Irina Alberg, Barbara Gräfen, Sascha Schmitt, Lydia Braun, Arthur H A M van Onzen, Raffaella Rossin, Kaloian Koynov, Hannes Mikula and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomacromolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Stefan KramerJohannes Gutenberg University Mainz , Institute of Organic Chemistry , Duesbergweg 10-14 , 55128 Mainz , Germany.
Dennis SvatunekTU Wien , Institute of Applied Synthetic Chemistry , Getreidemarkt 9 , 1060 Vienna , Austria.
Irina AlbergJohannes Gutenberg University Mainz , Institute of Organic Chemistry , Duesbergweg 10-14 , 55128 Mainz , Germany.
Barbara GräfenJohannes Gutenberg University Mainz , Institute of Organic Chemistry , Duesbergweg 10-14 , 55128 Mainz , Germany.
Sascha SchmittMax Planck Institute for Polymer Research , Physics of Interfaces , Ackermannweg 10 , 55128 Mainz , Germany.
Lydia BraunJohannes Gutenberg University Mainz , Institute of Organic Chemistry , Duesbergweg 10-14 , 55128 Mainz , Germany.
Arthur H A M van OnzenTagworks Pharmaceuticals BV, Radboud University Medical Center , Department of Nuclear Medicine and Radiology , 6500 HB Nijmegen , The Netherlands.
Raffaella RossinTagworks Pharmaceuticals BV, Radboud University Medical Center , Department of Nuclear Medicine and Radiology , 6500 HB Nijmegen , The Netherlands.
Kaloian KoynovMax Planck Institute for Polymer Research , Physics of Interfaces , Ackermannweg 10 , 55128 Mainz , Germany.ORCID 0000-0002-4062-8834
Hannes MikulaTU Wien , Institute of Applied Synthetic Chemistry , Getreidemarkt 9 , 1060 Vienna , Austria.ORCID 0000-0002-9218-9722
Rudolf ZentelJohannes Gutenberg University Mainz , Institute of Organic Chemistry , Duesbergweg 10-14 , 55128 Mainz , Germany.ORCID 0000-0001-9206-6047

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fast and bioorthogonally reacting nanoparticles are attractive tools for biomedical applications such as tumor pretargeting. In this study, we designed an amphiphilic block copolymer system based on HPMA using different strategies to introduce the highly reactive click units 1,2,4,5-tetrazines (Tz) either at the chain end (Tz-CTA) or statistical into the hydrophobic block. This reactive group undergoes a rapid, bioorthogonal inverse electron-demand Diels-Alder reaction (iEDDA) with

Indexed as

Aza CompoundsBenzene DerivativesClick ChemistryColloidsCross-Linking ReagentsCycloaddition ReactionMethacrylatesMicellesNanoparticles1,2,4,5-tetrazineAza CompoundsBenzene DerivativesColloidsCross-Linking Reagentshydroxypropyl methacrylateMethacrylatesMicelles

Identifiers

PMID31535846
PMCPMC6794642

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.