Evidence map›Paper›PMID 31535687›Full record

ArticleCarcinogenesis2020

Plasma hsa_circ_0027089 is a diagnostic biomarker for hepatitis B virus-related hepatocellular carcinoma.

Kai Zhu, Hao Zhan, Yuanfei Peng, Liuxiao Yang, Qiang Gao, Hao Jia, Zhi Dai, Zhaoyou Tang, Jia Fan, Jian Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Carcinogenesis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  4. Roles and Applications of Circular RNA in Virus Infection.International journal of molecular sciences · 2025
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  18. Emerging roles of circular RNAs in liver cancer.JHEP reports : innovation in hepatology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kai ZhuDepartment of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratorsy of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.
Hao ZhanDepartment of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratorsy of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.
Yuanfei PengDepartment of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratorsy of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.
Liuxiao YangDepartment of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratorsy of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.
Qiang GaoDepartment of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratorsy of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.
Hao JiaFaculty of Basic Medicine, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Zhi DaiDepartment of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratorsy of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.
Zhaoyou TangDepartment of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratorsy of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.
Jia FanDepartment of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratorsy of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.
Jian ZhouDepartment of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratorsy of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) have recently been identified as a new member of endogenous noncoding RNAs. CircRNAs exhibit high stability and can thus can be used as valuable biomarkers for monitoring the occurrence and development of hepatocellular carcinoma (HCC). The present study sought to explore the diagnostic significance of plasma circRNAs in hepatitis B virus (HBV)-related HCC. Plasma circRNAs from 10 patients with hepatitis B (HBV)-related HCC and 5 patients with HBV-related liver cirrhosis were investigated by microarray to screen differentially expressed circRNAs, 157 upregulated and 161 downregulated circRNAs were found. Twenty-four circRNAs were further investigated via quantitative reverse-transcriptase-polymerase chain reaction assay in a training cohort (n = 48), hsa_circ_0027089 exhibited the highest significance and further distinguished 64 HCC patients from 40 cirrhosis patients and 72 healthy participants in a validation cohort. These results indicate that plasma hsa_circ_0027089 can serve as a new marker for the diagnosis of HBV-related HCC.

Indexed as

AdolescentAdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, HepatocellularFemaleGene Expression Regulation, NeoplasticHepatitis B virusHumansLiver CirrhosisLiver NeoplasmsMaleMiddle AgedRNA, CircularYoung AdultBiomarkers, TumorRNA, Circular

Identifiers

PMID31535687
PMCPMC7221502

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.