Evidence map›Paper›PMID 31535684›Full record

ArticleChemical communications (Cambridge, England)2019

Simple and robust polymer-based sensor for rapid cancer detection using serum.

Ngoc D B Le, Arvind K Singla, Yingying Geng, Jinsong Han, Kai Seehafer, Gyan Prakash, Daniel F Moyano, Charlene M Downey, Michael J Monument, Doha Itani and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ngoc D B LeDepartment of Chemistry, University of Massachusetts Amherst, 710 N. Pleasant St., Amherst, MA 01003, USA. rotello@chem.umass.edu.
Arvind K SinglaDepartment of Biochemistry and Molecular Biology, The McCaig Institute for Bone and Joint Health, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada.
Yingying GengDepartment of Chemistry, University of Massachusetts Amherst, 710 N. Pleasant St., Amherst, MA 01003, USA. rotello@chem.umass.edu.
Jinsong HanOrganisch-Chemisches Institut, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.
Kai SeehaferOrganisch-Chemisches Institut, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.
Gyan PrakashDepartment of Chemistry, University of Massachusetts Amherst, 710 N. Pleasant St., Amherst, MA 01003, USA. rotello@chem.umass.edu.
Daniel F MoyanoDepartment of Chemistry, University of Massachusetts Amherst, 710 N. Pleasant St., Amherst, MA 01003, USA. rotello@chem.umass.edu.
Charlene M DowneyDepartment of Biochemistry and Molecular Biology, The McCaig Institute for Bone and Joint Health, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada.
Michael J MonumentDepartment of Surgery, The McCaig Institute for Bone and Joint Health, Arnie Charbonneau Cancer Institute, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada.
Doha ItaniDepartment of Pathology and Laboratory Medicine, Calgary Laboratory Services/University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada.
Uwe H F BunzOrganisch-Chemisches Institut, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.ORCID http://orcid.org/0000-0002-9369-5387
Frank R JirikDepartment of Biochemistry and Molecular Biology, The McCaig Institute for Bone and Joint Health, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada.
Vincent M RotelloDepartment of Chemistry, University of Massachusetts Amherst, 710 N. Pleasant St., Amherst, MA 01003, USA. rotello@chem.umass.edu.ORCID http://orcid.org/0000-0002-5184-5439

Funding

CHEMISTRY-BIOLOGY INTERFACE PREDOCTORAL TRAINING GRANTST32GM008515 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI THOMPSON, LYNMARIE K. · 1995 to 2020
$4.3M
Recognition and Presentation of Alpha Helices using Nanoparticle ReceptorsR01GM077173 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ROTELLO, VINCENT M. · 2007 to 2018
$3.7M
NIGMS NIH HHS R01 GM077173NIGMS NIH HHS T32 GM008515
6 · The paper itself

Abstract

We report a polymer-based sensor that rapidly detects cancer based on changes in serum protein levels. Using three ratiometric fluorescence outputs, this simple system identifies early stage and metastatic lung cancer with a high level of accuracy exceeding many biomarker-based assays, making it an attractive strategy for point-of-care testing.

Indexed as

AnimalsBiomarkers, TumorBlood ProteinsFluorescenceFluorescent DyesHumansLung NeoplasmsMiceMice, TransgenicMolecular StructureNeoplasms, ExperimentalPoint-of-Care TestingPolymersBiomarkers, TumorBlood ProteinsFluorescent DyesPolymers

Identifiers

PMID31535684
PMCPMC6760871

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.