ArticleJournal of psychopharmacology (Oxford, England)2020
Urinary 11-nor-9-carboxy-tetrahydrocannabinol elimination in adolescent and young adult cannabis users during one month of sustained and biochemically-verified abstinence.
Article in Journal of psychopharmacology (Oxford, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03276221 (Cognitive Recovery With Cannabis Abstinence Among High School-Aged Adolescents), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cognitive Recovery With Cannabis Abstinence Among High School-Aged Adolescents
Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Contingency management is associated with positive changes in attitudes and reductions in cannabis use even after discontinuation of incentives among non-treatment seeking youth.Drug and alcohol dependence · 2024Trial
- Assessing changes in sleep across four weeks among adolescents randomized to incentivized cannabis abstinence.Drug and alcohol dependence · 2023Trial
- Cannabis use and sleep quality in daily life: An electronic daily diary study of adults starting cannabis for health concerns.Drug and alcohol dependence · 2023Trial
- Alcohol substitution during one month of cannabis abstinence among non-treatment seeking youth.Progress in neuro-psychopharmacology & biological psychiatry · 2021Trial
- Cannabis legalization and increasing cannabis use in the United States: Data from urine toxicology testing in emergency room patients.The International journal on drug policy · 2025Article
- Acute cannabis intoxication among the paediatric population.Frontiers in toxicology · 2025Review
- THC Vapor Inhalation Attenuates Hyperalgesia in Rats Using a Chronic Inflammatory Pain Model.The journal of pain · 2024Article
- Measuring the diversity gap of cannabis clinical trial participants compared to people who report using cannabis.Scientific reports · 2023Article
- A national population-based study of cannabis use and correlates among U.S. veterans prescribed opioids in primary care.BMC psychiatry · 2023Article
- Preliminary Evidence for Cannabis and Nicotine Urinary Metabolites as Predictors of Verbal Memory Performance and Learning Among Young Adults.Journal of the International Neuropsychological Society : JINS · 2021Article
- Assessing Changes in Symptoms of Depression and Anxiety During Four Weeks of Cannabis Abstinence Among Adolescents.Frontiers in psychiatry · 2021Article
- Trends in Cannabis-positive Urine Toxicology Test Results: US Veterans Health Administration Emergency Department Patients, 2008 to 2019.Journal of addiction medicineArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDespite adolescents and young adults being the most frequent users of cannabis, all information on cannabis drug testing interpretation is based on data from adults.
aimsThis study aimed to define the time course of urinary 11-nor-9-carboxy-tetrahydrocannabinol (THCCOOH) excretion among 70 adolescent and young adult cannabis users during 1 month of biochemically-verified cannabis abstinence.
methodsUrine specimens were collected at non-abstinent baseline and after 2, 3, 8, 15, 21 and 28 days of abstinence. Specimens were tested for THCCOOH with a 'rapid' immunoassay drug test and a confirmatory assay using liquid chromatography-tandem mass spectrometry, with a 5 ng/mL limit of quantitation. Elimination rate was tested using a population pharmacokinetics model. RESULTS/OUTCOMES: Participants had an average of 26 days of abstinence (SD = 6). Initial creatinine-adjusted THCCOOH concentration (CN-THCCOOH) was 148 ng/mg (SD = 157). Half-life was 2 days (SD = 5), with a 10-day window of detection (estimated range: 4-80 days). At the final timepoint and among those with > 25 days of abstinence ( CONCLUSIONS/
interpretationFindings underscore that, as with adults, detectable cannabinoid metabolites do not necessarily indicate recent use in adolescents and young adults. Algorithms that account for THCCOOH levels, assessed longitudinally and time between specimen collections are best equipped to confirm abstinence. CLINICAL
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.