Evidence map›Paper›PMID 31535538›Full record

ArticleJournal of biomedical optics2019

Spatial resolution in dynamic optical coherence elastography.

Mitchell A Kirby, Kanheng Zhou, John J Pitre, Liang Gao, David Li, Ivan Pelivanov, Shaozhen Song, Chunhui Li, Zhihong Huang, Tueng Shen and 2 more

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
  2. Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Local elasticity evaluation of acid-denatured collagen by photoacoustic spectroscopy.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mitchell A KirbyUniversity of Washington, Department of Bioengineering, Seattle, Washington, United States.
Kanheng ZhouUniversity of Washington, Department of Bioengineering, Seattle, Washington, United States.
John J PitreUniversity of Washington, Department of Bioengineering, Seattle, Washington, United States.
Liang GaoUniversity of Washington, Department of Bioengineering, Seattle, Washington, United States.
David LiUniversity of Washington, Department of Bioengineering, Seattle, Washington, United States.
Ivan PelivanovUniversity of Washington, Department of Bioengineering, Seattle, Washington, United States.
Shaozhen SongUniversity of Washington, Department of Bioengineering, Seattle, Washington, United States.
Chunhui LiUniversity of Dundee, School of Science and Engineering, Dundee, United Kingdom.
Zhihong HuangUniversity of Dundee, School of Science and Engineering, Dundee, United Kingdom.
Tueng ShenUniversity of Washington, Department of Ophthalmology, Seattle, Washington, United States.
Ruikang WangUniversity of Washington, Department of Bioengineering, Seattle, Washington, United States.
Matthew O'DonnellUniversity of Washington, Department of Bioengineering, Seattle, Washington, United States.

Funding

OPTICAL MICROANGIOGRAHY OF CEREBROVASCULAR PERFUSIONR01HL093140 · NHLBI · UNIVERSITY OF WASHINGTON · PI WANG, RUIKANG · 2008 to 2017
$4.2M
Optical coherence elastography of corneal dynamicsR01EY026532 · NEI · UNIVERSITY OF WASHINGTON · PI SHEN, TUENG T · 2016 to 2020
$2.9M
Sensitive tumor detection with magnetomotive imagingR01CA170734 · NCI · UNIVERSITY OF WASHINGTON · PI GAO, XIAOHU · 2012 to 2015
$1.8M
Non-invasive trapping and imaging of circulating tumor cells in the peripheral vaR01EB016034 · NIBIB · UNIVERSITY OF WASHINGTON · PI O'DONNELL, MATTHEW · 2013 to 2016
$1.7M
NON-INVASIVE REAL-TIME LABEL-FREE 3D IMAGING OF RETINAL MICROCIRCULATIONR01EY024158 · NEI · UNIVERSITY OF WASHINGTON · PI WANG, RUIKANG · 2014 to 2017
$1.7M
NCI NIH HHS R01 CA170734NEI NIH HHS R01 EY024158NEI NIH HHS R01 EY026532NHLBI NIH HHS R01 HL093140NIBIB NIH HHS R01 EB016034
6 · The paper itself

Abstract

Dynamic optical coherence elastography (OCE) tracks elastic wave propagation speed within tissue, enabling quantitative three-dimensional imaging of the elastic modulus. We show that propagating mechanical waves are mode converted at interfaces, creating a finite region on the order of an acoustic wavelength where there is not a simple one-to-one correspondence between wave speed and elastic modulus. Depending on the details of a boundary’s geometry and elasticity contrast, highly complex propagating fields produced near the boundary can substantially affect both the spatial resolution and contrast of the elasticity image. We demonstrate boundary effects on Rayleigh waves incident on a vertical boundary between media of different shear moduli. Lateral resolution is defined by the width of the transition zone between two media and is the limit at which a physical inclusion can be detected with full contrast. We experimentally demonstrate results using a spectral-domain OCT system on tissue-mimicking phantoms, which are replicated using numerical simulations. It is shown that the spatial resolution in dynamic OCE is determined by the temporal and spatial characteristics (i.e., bandwidth and spatial pulse width) of the propagating mechanical wave. Thus, mechanical resolution in dynamic OCE inherently differs from the optical resolution of the OCT imaging system.

Indexed as

AlgorithmsComputer SimulationElasticity Imaging TechniquesElastic ModulusImage Processing, Computer-AssistedPhantoms, ImagingTomography, Optical Coherencecontrastdynamic elastographygroup velocityoptical coherence elastographyoptical coherence tomographyresolutionshear modulustissue elasticity

Identifiers

PMID31535538
PMCPMC6749618

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.