Evidence map›Paper›PMID 31535355›Full record

ArticleNeurochemical research2019

The Mitochondrial Targets of Neuroprotective Drug Vinpocetine on Primary Neuron Cultures, Brain Capillary Endothelial Cells, Synaptosomes, and Brain Mitochondria.

Gergely Svab, Judit Doczi, Akos A Gerencser, Attila Ambrus, Ferenc Gallyas, Balazs Sümegi, László Tretter

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurochemical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Gergely SvabDepartment of Medical Biochemistry, MTA-SE Laboratory for Neurobiochemistry, Semmelweis University, 37-47 Tuzolto Street, Budapest, 1094, Hungary.
Judit DocziDepartment of Medical Biochemistry, MTA-SE Laboratory for Neurobiochemistry, Semmelweis University, 37-47 Tuzolto Street, Budapest, 1094, Hungary.
Akos A GerencserDepartment of Medical Biochemistry, MTA-SE Laboratory for Neurobiochemistry, Semmelweis University, 37-47 Tuzolto Street, Budapest, 1094, Hungary.
Attila AmbrusDepartment of Medical Biochemistry, MTA-SE Laboratory for Neurobiochemistry, Semmelweis University, 37-47 Tuzolto Street, Budapest, 1094, Hungary.
Ferenc GallyasDepartment of Biochemistry and Medical Chemistry, University of Pecs Medical School, Pecs, Hungary.
Balazs SümegiDepartment of Biochemistry and Medical Chemistry, University of Pecs Medical School, Pecs, Hungary.
László TretterDepartment of Medical Biochemistry, MTA-SE Laboratory for Neurobiochemistry, Semmelweis University, 37-47 Tuzolto Street, Budapest, 1094, Hungary. tretter.laszlo@med.semmelweis-univ.hu.ORCID http://orcid.org/0000-0001-5638-2886
Semmelweis University · HUHungarian Academy of Sciences · HU

Funding

Brain and Behavior Research Foundation (US) 2017-1.2.1-NKP-2017-00002Hungarian Academy of Sciences Hungarian Academy of SciencesHungarian Brain Research Program 2017-1.2.1-NKP-2017-00002),Hungarian Brain Research Program (KTIA_13_NAP-A-III/6
6 · The paper itself

Abstract

Vinpocetine is considered as neuroprotectant drug and used for treatment of brain ischemia and cognitive deficiencies for decades. A number of enzymes, channels and receptors can bind vinpocetine, however the mechanisms of many effects' are still not clear. The present study investigated the effects of vinpocetine from the mitochondrial bioenergetic aspects. In primary brain capillary endothelial cells the purinergic receptor-stimulated mitochondrial Ca

Indexed as

AnimalsBrainCalciumEndothelial CellsHydrogen PeroxideMembrane Potential, MitochondrialMitochondriaNeuronsNeuroprotective AgentsRats, WistarSynaptosomesVinca AlkaloidsCalciumHydrogen PeroxideNeuroprotective AgentsVinca AlkaloidsvinpocetineATP synthesisCalcium induced calcium releaseMitochondriaNeuroprotectionOxygen consumptionReactive oxygen speciesUncouplingVinpocetine

Identifiers

PMID31535355
PMCPMC6776483
OpenAlexW2973702980

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.