ArticleIntensive care medicine experimental2019
Respiratory and metabolic acidosis correction with the ADVanced Organ Support system.
Article in Intensive care medicine experimental, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Extracorporeal Multiorgan Support During Prone Positioning in Severe ARDS: A Physiologic Proof-of-Concept Study.Life (Basel, Switzerland) · 2026Article
- The ADVanced Organ Support (ADVOS) hemodialysis system balances blood pH within 24 h in patients with multiple organ failure and hypercapnic acidosis.Intensive care medicine experimental · 2025Article
- The ADVanced Organ Support (ADVOS) Hemodialysis System in Postoperative Cardiogenic Shock and Multiple Organ Failure: First Results in Cardiac Surgery Patients.Life (Basel, Switzerland) · 2025Article
- Lactate dehydrogenase to albumin ratio and poor prognosis after thrombolysis in ischemic stroke patients: developing a novel nomogram.BMC medical informatics and decision making · 2025Article
- Article
- The ADVanced Organ Support (ADVOS) hemodialysis system removes IL-6: an in vitro proof-of-concept study.Intensive care medicine experimental · 2024Article
- Extracorporeal albumin dialysis in critically ill patients with liver failure: Comparison of four different devices-A retrospective analysis.The International journal of artificial organs · 2023Article
- Construction of a nomogram predictive model for patients with liver rupture undergoing surgical intervention.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2023Article
- The role of the ADVanced Organ Support (ADVOS) system in critically ill patients with multiple organ failure.Artificial organs · 2022Review
- Trends, Advantages and Disadvantages in Combined Extracorporeal Lung and Kidney Support From a Technical Point of View.Frontiers in medical technology · 2022Review
- Extracorporeal carbon dioxide removal with the Advanced Organ Support system in critically ill COVID-19 patients.Artificial organs · 2021Observational
- Possibility of Venous Serum ClInternational journal of molecular sciences · 2021Article
- Extracorporeal multiorgan support including COThe International journal of artificial organs · 2021Article
- The Pyruvate Dehydrogenase Complex in Sepsis: Metabolic Regulation and Targeted Therapy.Frontiers in nutrition · 2021Review
- Advanced organ support (ADVOS) in the critically ill: first clinical experience in patients with multiple organ failure.Annals of intensive care · 2020Article
- Options in extracorporeal support of multiple organ failure.Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe lung, the kidney, and the liver are major regulators of acid-base balance. Acidosis due to the dysfunction of one or more organs can increase mortality, especially in critically ill patients. Supporting compensation by increasing ventilation or infusing bicarbonate is often ineffective. Therefore, direct removal of acid may represent a novel therapeutic approach. This can be achieved with the ADVanced Organ Support (ADVOS) system, an enhanced renal support therapy based on albumin dialysis. Here, we demonstrate proof of concept for this technology.
methodsAn ex vivo model of either hypercapnic (i.e., continuous CO
resultsSixty-one milliliters per minute (2.7 mmol/min) of CO
conclusionsIn conclusion, ADVOS was able to remove more than 50% of the amount of CO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.