Evidence map›Paper›PMID 31535222›Full record

ArticleJournal of materials science. Materials in medicine2019

Titanium alloys: in vitro biological analyzes on biofilm formation, biocompatibility, cell differentiation to induce bone formation, and immunological response.

Daphne de Camargo Reis Mello, Jonatas Rafael de Oliveira, Carlos Alberto Alves Cairo, Lais Siebra de Brito Ramos, Mariana Raquel da Cruz Vegian, Luis Gustavo Oliveira de Vasconcellos, Felipe Eduardo de Oliveira, Luciane Dias de Oliveira, Luana Marotta Reis de Vasconcellos

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In one paragraph

Article in Journal of materials science. Materials in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Daphne de Camargo Reis MelloDepartment of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (UNESP), Av. Engenheiro Francisco José Longo, 777, São José dos Campos, SP, CEP12245-000, Brazil.
Jonatas Rafael de OliveiraDepartment of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (UNESP), Av. Engenheiro Francisco José Longo, 777, São José dos Campos, SP, CEP12245-000, Brazil. jroliveira16@hotmail.com.ORCID http://orcid.org/0000-0003-2398-6506
Carlos Alberto Alves CairoDivision of Materials, Air and Space Institute (CTA), Praça Marechal do Ar Eduardo Gomes, 14, São José dos Campos, SP, CEP 12904-000, Brazil.
Lais Siebra de Brito RamosDepartment of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (UNESP), Av. Engenheiro Francisco José Longo, 777, São José dos Campos, SP, CEP12245-000, Brazil.
Mariana Raquel da Cruz VegianDepartment of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (UNESP), Av. Engenheiro Francisco José Longo, 777, São José dos Campos, SP, CEP12245-000, Brazil.
Luis Gustavo Oliveira de VasconcellosDepartment of Materials and Dental Prosthodontics, Institute of Science and Technology, São Paulo State University (UNESP), Av. Engenheiro Francisco José Longo, 777, São José dos Campos, SP, CEP12245-000, Brazil.
Felipe Eduardo de OliveiraBrazcubas Faculty of Dentistry, University Center Brazcubas, Av. Francisco Rodrigues Filho, 1233, Mogi das Cruzes, SP, CEP 08773-380, Brazil.
Luciane Dias de OliveiraDepartment of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (UNESP), Av. Engenheiro Francisco José Longo, 777, São José dos Campos, SP, CEP12245-000, Brazil.
Luana Marotta Reis de VasconcellosDepartment of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (UNESP), Av. Engenheiro Francisco José Longo, 777, São José dos Campos, SP, CEP12245-000, Brazil.
Universidade Estadual Paulista (Unesp) · BRDepartment of Aerospace Science and Technology · BRUniversidade Braz Cubas · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2012/20311-8
6 · The paper itself

Abstract

Biological effects of titanium (Ti) alloys were analyzed on biofilms of Candida albicans, Enterococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus mutans, and Streptococcus sanguinis, as well as on osteoblast-like cells (MG63) and murine macrophages (RAW 264.7). Standard samples composed of aluminum and vanadium (Ti-6Al-4V), and sample containing niobium (Ti-35Nb) and zirconium (Ti-13Nb-13Zr) were analyzed. Monomicrobial biofilms were formed on the Ti alloys. MG63 cells were grown with the alloys and the biocompatibility (MTT), total protein (TP) level, alkaline phosphatase (ALP) activity, and mineralization nodules (MN) formation were verified. Levels of interleukins (IL-1β and IL-17), tumor necrosis factor alpha (TNF-α), and oxide nitric (NO) were checked, from RAW 264.7 cells supernatants. Data were statically analyzed by one-way analysis of variance (ANOVA) and Tukey's test, or T-test (P ≤ 0.05). Concerning the biofilm formation, Ti-13Nb-13Zr alloy showed the best inhibitory effect on E. faecalis, P. aeruginosa, and S. aureus. And, it also acted similarly to the Ti-6Al-4V alloy on C. albicans and Streptococcus spp. Both alloys were biocompatible and similar to the Ti-6Al-4V alloy. Additionally, Ti-13Nb-13Zr alloy was more effective for cell differentiation, as observed in the assays of ALP and MN. Regarding the stimulation for release of IL-1β and TNF-α, Ti-35Nb and Ti-13Nb-13Zr alloys inhibited similarly the synthesis of these molecules. However, both alloys stimulated the production of IL-17. Additionally, all Ti alloys showed the same effect for NO generation. Thus, Ti-13Nb-13Zr alloy was the most effective for inhibition of biofilm formation, cell differentiation, and stimulation for release of immune mediators.

Indexed as

AlloysAnimalsBiocompatible MaterialsBiofilmsCandida albicansCell DifferentiationCells, CulturedMaterials TestingMiceMicrobial Sensitivity TestsOsteoblastsOsteogenesisPseudomonasRAW 264.7 CellsStaphylococcus aureusStreptococcusAlloysBiocompatible MaterialsTitanium

Identifiers

PMID31535222
OpenAlexW2973926419

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.