Trial reportThe American journal of clinical nutrition2019
Weight gain is associated with changes in neural response to palatable food tastes varying in sugar and fat and palatable food images: a repeated-measures fMRI study.
Trial report in The American journal of clinical nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01949636 (An fMRI Test of the Dynamic Vulnerability Model of Obesity), which is not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An fMRI Test of the Dynamic Vulnerability Model of Obesity: Risk Factor Plasticity
Who cites it
24 citing papers in PubMed.
- Enhancing Efficacy of a Brief Obesity and Eating Disorder Prevention Program: Long-Term Results from an Experimental Therapeutics Trial.Nutrients · 2023Trial
- The Effect of a 14-DayNutrients · 2022Trial
- Combination therapy with exenatide decreases the dapagliflozin-induced changes in brain responses to anticipation and consumption of palatable food in patients with type 2 diabetes: A randomized controlled trial.Diabetes, obesity & metabolism · 2022Trial
- Enhancing efficacy of a dissonance-based obesity and eating disorder prevention program: Experimental therapeutics.Journal of consulting and clinical psychology · 2021Trial
- Article
- Savoring Satiety: An Exploratory Analysis of the Neural Correlates of Sensory-Specific Satiety.Nutrients · 2025Article
- The development and testing of the TTU food cue reactivity image bank.International journal of obesity (2005) · 2025Article
- Efficacy of a Web-Based Executive Function Training Program to Induce Healthier Food Choices and Increase Valuation of Fruits and Vegetables in Adults: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2025Article
- Sensory and neural responses to flavor compound 3-Methylbutanal in dry fermented sausages: Enhancing perceived overall aroma.Food chemistry: X · 2025Article
- Relation of BOLD response to food-specific and generic motor response inhibition tasks to body fat gain in adults with overweight and obesity.Physiology & behavior · 2023Article
- Contextualizing the Neural Vulnerabilities Model of Obesity.Nutrients · 2023Review
- Food memory circuits regulate eating and energy balance.Current biology : CB · 2023Article
- Brain Responses to Food Choices and Decisions Depend on Individual Hedonic Profiles and Eating Habits in Healthy Young Women.Frontiers in nutrition · 2022Article
- Neural responsiveness to Chinese versus Western food images: An functional magnetic resonance imaging study of Chinese young adults.Frontiers in nutrition · 2022Article
- Neural Vulnerability Factors That Predict Future Weight Gain.Current obesity reports · 2021Review
- Test-retest reliability of functional MRI food receipt, anticipated receipt, and picture tasks.The American journal of clinical nutrition · 2021Article
- Associations Between Exposure to Gestational Diabetes Mellitus In Utero and Daily Energy Intake, Brain Responses to Food Cues, and Adiposity in Children.Diabetes care · 2021Article
- An Exploration of the Role of Sugar-Sweetened Beverage in Promoting Obesity and Health Disparities.Current obesity reports · 2021Review
- Longitudinal Associations Between Taste Sensitivity, Taste Liking, Dietary Intake and BMI in Adolescents.Frontiers in psychology · 2021Article
- Much Ado About Missingness: A Demonstration of Full Information Maximum Likelihood Estimation to Address Missingness in Functional Magnetic Resonance Imaging Data.Frontiers in neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEmerging data suggest that weight gain is associated with changes in neural response to palatable food tastes and palatable food cues, which may serve to maintain overeating.
objectiveWe investigated whether weight gain is associated with neural changes in response to tastes of milkshakes varying in fat and sugar content and palatable food images.
methodsWe compared changes in neural activity between initially healthy-weight adolescents who gained weight (n = 36) and those showing weight stability (n = 31) over 2-3 y.
resultsAdolescents who gained weight compared with those who remained weight stable showed decreases in activation in the postcentral gyrus, prefrontal cortex, insula, and anterior cingulate cortex, and increases in activation in the parietal lobe, posterior cingulate cortex, and inferior frontal gyrus in response to a high-fat/low-sugar compared with low-fat/low-sugar milkshake. Weight gainers also showed greater decreases in activation in the anterior insula and lateral orbitofrontal cortex in response to a high-fat/high-sugar compared with low-fat/low-sugar milkshake than those who remained weight stable. No group differences emerged in response to a low-fat/high-sugar compared with a low-fat/low-sugar milkshake. Weight gainers compared with those who remained weight stable showed greater decreases in activation in the middle temporal gyrus and increases in cuneus activation in response to appetizing compared with unappetizing food pictures. The significant interactions were partially driven by group differences in baseline responsivity and by opposite changes in neural activation in adolescents who remained weight stable.
conclusionsData suggest that weight gain is associated with a decrease in responsivity of regions associated with taste and reward processing to palatable high-fat- and high-fat/high-sugar food tastes. Data also suggest that avoiding weight gain increases taste sensitivity, which may prevent future excessive weight gain.This trial was registered at clinicaltrials.gov as NCT01949636.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.