Evidence map›Paper›PMID 31534975›Full record

ArticleJournal of immunology research2019

TNFAIP3 Gene Polymorphisms in Three Common Autoimmune Diseases: Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Primary Sjogren Syndrome-Association with Disease Susceptibility and Clinical Phenotypes in Italian Patients.

C Ciccacci, A Latini, C Perricone, P Conigliaro, S Colafrancesco, F Ceccarelli, R Priori, F Conti, R Perricone, G Novelli and 1 more

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 62 citations in OpenAlex.

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  15. Association betweenMedicina (Kaunas, Lithuania) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

C CiccacciUniCamillus, Saint Camillus International University of Health Sciences, Rome, Italy.ORCID https://orcid.org/0000-0002-3995-7032
A LatiniDepartment of Biomedicine and Prevention, Genetics Section, University of Rome Tor Vergata, Italy.
C PerriconeUOC Reumatologia, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Italy.ORCID https://orcid.org/0000-0003-4771-6981
P ConigliaroClinic of Rheumatology, Allergology and Clinical Immunology, Department of Medicina dei Sistemi, University of Rome Tor Vergata, Italy.
S ColafrancescoUOC Reumatologia, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Italy.
F CeccarelliUOC Reumatologia, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Italy.ORCID https://orcid.org/0000-0001-5026-8783
R PrioriUOC Reumatologia, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Italy.
F ContiUOC Reumatologia, Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma, Italy.ORCID https://orcid.org/0000-0002-1897-049X
R PerriconeClinic of Rheumatology, Allergology and Clinical Immunology, Department of Medicina dei Sistemi, University of Rome Tor Vergata, Italy.
G NovelliDepartment of Biomedicine and Prevention, Genetics Section, University of Rome Tor Vergata, Italy.
P BorgianiDepartment of Biomedicine and Prevention, Genetics Section, University of Rome Tor Vergata, Italy.
University of Rome Tor Vergata · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune diseases (AIDs) are complex diseases characterized by persistent or recurrent inflammation, alteration of immune response, and production of specific autoantibodies. It is known that different AIDs share several susceptibility genetic loci. Tumor necrosis factor alpha inducible protein 3 (TNFAIP3) encodes the ubiquitin-modifying enzyme A20, which downregulates inflammation by restricting NF-

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAllelesArthritis, RheumatoidAutoimmune DiseasesCase-Control StudiesGene FrequencyGenotypeHumansItalyLupus Erythematosus, SystemicPhenotypeSjogren's SyndromeTumor Necrosis Factor alpha-Induced Protein 3TNFAIP3 protein, humanTumor Necrosis Factor alpha-Induced Protein 3

Identifiers

PMID31534975
PMCPMC6732636
OpenAlexW2970301236

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.