Evidence map›Paper›PMID 31534844›Full record

ArticlePeerJ2019

Kombucha: a novel model system for cooperation and conflict in a complex multi-species microbial ecosystem.

Alexander May, Shrinath Narayanan, Joe Alcock, Arvind Varsani, Carlo Maley, Athena Aktipis

Open access · goldAbstract read
In one paragraph

Article in PeerJ, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 172 citations in OpenAlex.

  1. Article
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  4. Review
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  7. Article
  8. Food chemistry. Molecular sciences · 2025
    Article
  9. ThaiFoods (Basel, Switzerland) · 2025
    Article
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  19. Regulatory mechanisms and applications ofFrontiers in microbiology · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Alexander MaySchool of Life Sciences, Arizona State University, Tempe, AZ, USA.
Shrinath NarayananThe Biodesign Center for Biocomputing, Security and Society, Arizona State University, Tempe, AZ, USA.
Joe AlcockUniversity of New Mexico, Albuquerque, NM, USA.ORCID 0000-0003-0807-164X
Arvind VarsaniSchool of Life Sciences, Arizona State University, Tempe, AZ, USA.ORCID 0000-0003-4111-2415
Carlo MaleySchool of Life Sciences, Arizona State University, Tempe, AZ, USA.
Athena AktipisDepartment of Psychology, Arizona State University, Tempe, AZ, USA.ORCID 0000-0002-7128-670X
Biocom · USArizona State University · USUniversity of Cape Town · ZAUniversity of New Mexico · US

Funding

The Role of the Microbiome in Cancer Suppression and Susceptibility Across SpeciesU54CA217376 · NCI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI MALEY, CARLO · 2018 to 2022
$8.6M
NCI NIH HHS U54 CA217376
6 · The paper itself

Abstract

Kombucha, a fermented tea beverage with an acidic and effervescent taste, is composed of a multispecies microbial ecosystem with complex interactions that are characterized by both cooperation and conflict. In kombucha, a complex community of bacteria and yeast initiates the fermentation of a starter tea (usually black or green tea with sugar), producing a biofilm that covers the liquid over several weeks. This happens through several fermentative phases that are characterized by cooperation and competition among the microbes within the kombucha solution. Yeast produce invertase as a public good that enables both yeast and bacteria to metabolize sugars. Bacteria produce a surface biofilm which may act as a public good providing protection from invaders, storage for resources, and greater access to oxygen for microbes embedded within it. The ethanol and acid produced during the fermentative process (by yeast and bacteria, respectively) may also help to protect the system from invasion by microbial competitors from the environment. Thus, kombucha can serve as a model system for addressing important questions about the evolution of cooperation and conflict in diverse multispecies systems. Further, it has the potential to be artificially selected to specialize it for particular human uses, including the development of antimicrobial ecosystems and novel materials. Finally, kombucha is easily-propagated, non-toxic, and inexpensive, making it an excellent system for scientific inquiry and citizen science.

Indexed as

Artificial selectionBiofilmCommunityCompetitionConflictCooperationEvolutionFermentationMicrobiomeSymbiosis

Identifiers

PMID31534844
PMCPMC6730531
OpenAlexW2971783433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.