Evidence map›Paper›PMID 31534659›Full record

ArticleMedChemComm2019

Synthesis and biological evaluation of structurally diverse α-conformationally restricted chalcones and related analogues.

Casey J Maguire, Graham J Carlson, Jacob W Ford, Tracy E Strecker, Ernest Hamel, Mary Lynn Trawick, Kevin G Pinney

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedChemComm, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Casey J MaguireDepartment of Chemistry and Biochemistry , Baylor University , One Bear Place #97348 , Waco , TX 76798-7348 , USA . Email: Kevin_Pinney@baylor.edu ; Tel: +1 (254) 710 4117.
Graham J CarlsonDepartment of Chemistry and Biochemistry , Baylor University , One Bear Place #97348 , Waco , TX 76798-7348 , USA . Email: Kevin_Pinney@baylor.edu ; Tel: +1 (254) 710 4117.
Jacob W FordDepartment of Chemistry and Biochemistry , Baylor University , One Bear Place #97348 , Waco , TX 76798-7348 , USA . Email: Kevin_Pinney@baylor.edu ; Tel: +1 (254) 710 4117.
Tracy E StreckerDepartment of Chemistry and Biochemistry , Baylor University , One Bear Place #97348 , Waco , TX 76798-7348 , USA . Email: Kevin_Pinney@baylor.edu ; Tel: +1 (254) 710 4117.
Ernest HamelScreening Technologies Branch , Developmental Therapeutics Program , Division of Cancer Treatment and Diagnosis , National Cancer Institute , Frederick National Laboratory for Cancer Research , National Institutes of Health , Frederick , MD 21702 , USA.ORCID 0000-0003-3648-103X
Mary Lynn TrawickDepartment of Chemistry and Biochemistry , Baylor University , One Bear Place #97348 , Waco , TX 76798-7348 , USA . Email: Kevin_Pinney@baylor.edu ; Tel: +1 (254) 710 4117.
Kevin G PinneyDepartment of Chemistry and Biochemistry , Baylor University , One Bear Place #97348 , Waco , TX 76798-7348 , USA . Email: Kevin_Pinney@baylor.edu ; Tel: +1 (254) 710 4117.ORCID 0000-0003-1262-8631

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous members of the combretastatin and chalcone families of natural products function as inhibitors of tubulin polymerization through a binding interaction at the colchicine site on β-tubulin. These molecular scaffolds inspired the development of many structurally modified derivatives and analogues as promising anticancer agents. A productive design blueprint that involved molecular hybridization of the pharmacophore moieties of combretastatin A-4 (

Identifiers

PMID31534659
PMCPMC6734540

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.