ArticleMedChemComm2019
Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.
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Article in MedChemComm, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
–field-weighted citation impact
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- High-efficient discovering the potent anti-Notum agents from herbal medicines for combating glucocorticoid-induced osteoporosis.Acta pharmaceutica Sinica. B · 2025Article
- Silencing of a Pectin Acetylesterase (PAE) Gene Highly Expressed in Tobacco Pistils Negatively Affects Pollen Tube Growth.Plants (Basel, Switzerland) · 2023Article
- Structural Analysis and Development of Notum Fragment Screening Hits.ACS chemical neuroscience · 2022Article
- Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.Journal of medicinal chemistry · 2022Article
- Notum Deletion From Late-Stage Skeletal Cells Increases Cortical Bone Formation and Potentiates Skeletal Effects of Sclerostin Inhibition.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Article
- Structural Insights into Notum Covalent Inhibition.Journal of medicinal chemistry · 2021Article
- Wnt signaling activation: targets and therapeutic opportunities for stem cell therapy and regenerative medicine.RSC chemical biology · 2021Review
- Small-molecule inhibitors of carboxylesterase Notum.Future medicinal chemistry · 2021Review
- Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling.Journal of medicinal chemistry · 2021Article
- Caffeine inhibits Notum activity by binding at the catalytic pocket.Communications biology · 2020Article
- Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum.Journal of pineal research · 2020Article
- Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors.Bioorganic & medicinal chemistry letters · 2020Article
- An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent.Beilstein journal of organic chemistry · 2019Article
Corrections and comments
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Authors and funding
14 authors.
Benjamin N AtkinsonAlzheimer's Research UK UCL Drug Discovery Institute , University College London , Cruciform Building, Gower Street , London , WC1E 6BT , UK . Email: p.fish@ucl.ac.uk ; Tel: +44 (0)20 7679 6971.ORCID 0000-0001-5511-9859
David SteadmanAlzheimer's Research UK UCL Drug Discovery Institute , University College London , Cruciform Building, Gower Street , London , WC1E 6BT , UK . Email: p.fish@ucl.ac.uk ; Tel: +44 (0)20 7679 6971.ORCID 0000-0003-4271-5525
Yuguang ZhaoDivision of Structural Biology , Wellcome Centre for Human Genetics , University of Oxford , The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive , Oxford , OX3 7BN , UK . Email: yvonne@strubi.ox.ac.uk ; Tel: +44 (0)1865 287 546.
James SipthorpAlzheimer's Research UK UCL Drug Discovery Institute , University College London , Cruciform Building, Gower Street , London , WC1E 6BT , UK . Email: p.fish@ucl.ac.uk ; Tel: +44 (0)20 7679 6971.ORCID 0000-0002-6838-8043
Luca VecchiaDivision of Structural Biology , Wellcome Centre for Human Genetics , University of Oxford , The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive , Oxford , OX3 7BN , UK . Email: yvonne@strubi.ox.ac.uk ; Tel: +44 (0)1865 287 546.ORCID 0000-0003-0531-3180
Reinis R RuzaDivision of Structural Biology , Wellcome Centre for Human Genetics , University of Oxford , The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive , Oxford , OX3 7BN , UK . Email: yvonne@strubi.ox.ac.uk ; Tel: +44 (0)1865 287 546.ORCID 0000-0002-0509-3512
Fiona JeganathanAlzheimer's Research UK UCL Drug Discovery Institute , University College London , Cruciform Building, Gower Street , London , WC1E 6BT , UK . Email: p.fish@ucl.ac.uk ; Tel: +44 (0)20 7679 6971.
Georgie LinesAlzheimer's Research UK UCL Drug Discovery Institute , University College London , Cruciform Building, Gower Street , London , WC1E 6BT , UK . Email: p.fish@ucl.ac.uk ; Tel: +44 (0)20 7679 6971.
Sarah FrewAlzheimer's Research UK UCL Drug Discovery Institute , University College London , Cruciform Building, Gower Street , London , WC1E 6BT , UK . Email: p.fish@ucl.ac.uk ; Tel: +44 (0)20 7679 6971.
Amy MonaghanAlzheimer's Research UK UCL Drug Discovery Institute , University College London , Cruciform Building, Gower Street , London , WC1E 6BT , UK . Email: p.fish@ucl.ac.uk ; Tel: +44 (0)20 7679 6971.
Svend KjærThe Francis Crick Institute , 1 Midland Road , London , NW1 1AT , UK.
Magda BictashAlzheimer's Research UK UCL Drug Discovery Institute , University College London , Cruciform Building, Gower Street , London , WC1E 6BT , UK . Email: p.fish@ucl.ac.uk ; Tel: +44 (0)20 7679 6971.
E Yvonne JonesDivision of Structural Biology , Wellcome Centre for Human Genetics , University of Oxford , The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive , Oxford , OX3 7BN , UK . Email: yvonne@strubi.ox.ac.uk ; Tel: +44 (0)1865 287 546.ORCID 0000-0002-3834-1893
Paul V FishAlzheimer's Research UK UCL Drug Discovery Institute , University College London , Cruciform Building, Gower Street , London , WC1E 6BT , UK . Email: p.fish@ucl.ac.uk ; Tel: +44 (0)20 7679 6971.ORCID 0000-0002-2117-2173
Funding
Cancer Research UK 17721Medical Research Council FC001002
Abstract
NOTUM is a carboxylesterase that has been shown to act by mediating the
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.