ArticleJournal of dental sciences2019
Diagnostic accuracy of salivary biomarkers of bone turnover in identifying patients with periodontitis in a Saudi Arabian population.
Article in Journal of dental sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Investigation of the expression of the C-terminal cross-linking telopeptide of type I collagen (CTXI) in saliva during early and delayed loading of dental implants.BMC oral health · 2025Trial
- Salivary Osteocalcin as Potential Diagnostic Marker of Periodontal Bone Destruction among Smokers.Biomolecules · 2020Trial
- Oral and Gingival Crevicular Fluid Biomarkers for Jawbone Turnover Diseases: A Scoping Review.Diagnostics (Basel, Switzerland) · 2024Article
- Association between Chronological Age and IGF-1, IGFBP-3, and CTX Levels in Saliva of Children through Younger Adult Population with Varying Periodontal Status.Children (Basel, Switzerland) · 2022Article
- Bone markers and bone mineral density associates with periodontitis in females with poly-cystic ovarian syndrome.Journal of bone and mineral metabolism · 2022Article
- Comparison of Salivary IGF-1, IGFBP-3, and CTX with Periodontal Status among Patients Belonging to Various Skeletal Maturity Groups.Oral health & preventive dentistry · 2022Article
- Effect ofMolecules (Basel, Switzerland) · 2020Article
- Evaluation of Osteocalcin Levels in Saliva of Periodontitis Patients and Their Correlation with the Disease Severity: A Cross-Sectional Study.European journal of dentistry · 2020Article
- Review
- Muscle-Bone Crosstalk in the Masticatory System: From Biomechanical to Molecular Interactions.Frontiers in endocrinology · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background/purposeSalivary markers of bone turnover are useful biomarkers for screening patients advanced periodontal diseases with alveolar bone loss. Hence, the purpose of this study was to determine the diagnostic accuracy of deoxypyridinoline-containing degradation fragment of the C-terminal telopeptide region of type I collagen (CTX), Osteocalcin (OC) and Osteonectin (ON) in identifying patients with alveolar bone loss (BL) due to periodontitis. MATERIALS AND
methodSalivary levels of CTX, OC and ON were evaluated in ninety patients (group I, II and III with healthy, periodontitis without Type2 diabetes mellitus-T2DM and periodontitis with T2DM respectively). Group III was included since T2DM is very common among patients attending our clinics. Bleeding on probing (BOP), probing pocket depth (PPD) and BL were recorded for these patients.
resultsThe concentrations of salivary CTX, OC, and ON were higher in subjects with periodontitis than in controls. Significant correlations were found between these biomarkers and periodontal parameters. CTX, OC, and ON could discriminate between healthy (group I) and diseased (group II & III) regarding BL with excellent sensitivity (90.2-100%) and good specificity (62.1-96.6%). ROC curve gave excellent discrimination regarding BL (AUC: 0.926-0.958) and PPD (AUC: 0.904-0.915). However, none of the cut-off values gave good discrimination regarding BOP.
conclusionIt can be concluded that CTX, OC, and ON correlated well with BL and PPD. Among the three biomarkers, ON at 81.80 ng/ml gave the best discrimination for presence or absence of bone loss.
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