Evidence map›Paper›PMID 31534631›Full record

ArticleOncotarget2019

One-bead one-compound combinatorial library derived targeting ligands for detection and treatment of oral squamous cancer.

Fan Yang, Wenwu Xiao, Yanlei Liu, Ruiwu Liu, Randall Kramer, Xiaocen Li, Yousif Ajena, Christopher M Baehr, Tatu Rojalin, Hongyong Zhang and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Fan YangDepartment of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA.
Wenwu XiaoDepartment of Biochemistry and Molecular Medicine, University of California, Davis, CA, USA.
Yanlei LiuDepartment of Pathology, University of California Davis Medical Center, Sacramento, CA, USA.
Ruiwu LiuDepartment of Biochemistry and Molecular Medicine, University of California, Davis, CA, USA.
Randall KramerDepartment of Cell and Tissue Biology, University of California, San Francisco, CA, USA.
Xiaocen LiDepartment of Biochemistry and Molecular Medicine, University of California, Davis, CA, USA.
Yousif AjenaDepartment of Biochemistry and Molecular Medicine, University of California, Davis, CA, USA.
Christopher M BaehrDepartment of Biochemistry and Molecular Medicine, University of California, Davis, CA, USA.
Tatu RojalinDepartment of Biochemistry and Molecular Medicine, University of California, Davis, CA, USA.
Hongyong ZhangDepartment of Biochemistry and Molecular Medicine, University of California, Davis, CA, USA.
Kit S LamDepartment of Biochemistry and Molecular Medicine, University of California, Davis, CA, USA.
University of California, Davis · USHarvard University · USUniversity of California Davis Medical Center · USUniversity of California, San Francisco · US

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Gina M Dayton · 2002 to 2026
$84.9M
NCI NIH HHS P30 CA093373
6 · The paper itself

Abstract

Oral squamous cancers (OSC) are hallmarked by poor prognosis, delayed clinical detection, and a lack of defined, characteristic biomarkers. By screening combinatorial one-bead one-compound (OBOC) peptide libraries against oral squamous cancer cell lines, two cyclic peptide ligands, LLY12 and LLY13 were previously identified. These ligands are capable of specific binding to the oral cancer cell lines (MOK-101, HSC-3, SCC-4 and SCC-10a) but not non-cancerous keratinocytes, leukocytes, fibroblast, and endothelial cells. These two peptides were synthesized and evaluated for their binding property, cytotoxicity and cell permeability.

Indexed as

cancer-targeting peptideoptical imagingoral squamous cancerorthotopic xenograft modelα3 integrin

Identifiers

PMID31534631
PMCPMC6739215
OpenAlexW2980297375

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.