Evidence map›Paper›PMID 31534537›Full record

ArticleTheranostics2019

Copy number gain of ZEB1 mediates a double-negative feedback loop with miR-33a-5p that regulates EMT and bone metastasis of prostate cancer dependent on TGF-β signaling.

Yuhu Dai, Zhengquan Wu, Chuandong Lang, Xin Zhang, Shaofu He, Qing Yang, Wei Guo, Yingrong Lai, Hong Du, Xinsheng Peng and 1 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Unveiling the mechanisms and challenges of cancer drug resistance.Cell communication and signaling : CCS · 2024
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Muscle and Bone Defects in Metastatic Disease.Current osteoporosis reports · 2022
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Yuhu DaiDepartment of Orthopaedic Surgery, the First Affiliated Hospital of Sun Yat-sen University, 510080, Guangzhou, China.
Zhengquan WuDepartment of Orthopaedic Surgery, the First Affiliated Hospital of Sun Yat-sen University, 510080, Guangzhou, China.
Chuandong LangDepartment of Orthopaedic Surgery, the First Affiliated Hospital of Sun Yat-sen University, 510080, Guangzhou, China.
Xin ZhangClinical Experimental Center, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-sen University, Jiangmen, China.
Shaofu HeDepartment of radiology, the First Affiliated Hospital of Sun Yat-sen University, 510080, Guangzhou, China.
Qing YangDepartment of Orthopaedic Surgery, the First Affiliated Hospital of Sun Yat-sen University, 510080, Guangzhou, China.
Wei GuoDepartment of Orthopaedic Surgery, the First Affiliated Hospital of Sun Yat-sen University, 510080, Guangzhou, China.
Yingrong LaiDepartment of Pathology, the First Affiliated Hospital of Sun Yat-sen University, 510080, Guangzhou, China.
Hong DuDepartment of Pathology, the First People's Hospital of Guangzhou City, 510180, Guangzhou, Guangdong Province, China.
Xinsheng PengDepartment of Orthopaedic Surgery, the First Affiliated Hospital of Sun Yat-sen University, 510080, Guangzhou, China.
Dong RenDepartment of Orthopaedic Surgery, the First Affiliated Hospital of Sun Yat-sen University, 510080, Guangzhou, China.
Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA Copy Number VariationsSignal TransductionAnimalsBone NeoplasmsDown-RegulationEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansMaleMiceMicroRNAsProstatic NeoplasmsTransforming Growth Factor betaUp-RegulationZinc Finger E-box-Binding Homeobox 1MicroRNAsMIRN33a microRNA, humanMirn33 microRNA, mouseTransforming Growth Factor betaZEB1 protein, humanZinc Finger E-box-Binding Homeobox 1miR-33a-5p, ZEB1, double negative feedback loop, bone metastasisprostate cancer

Identifiers

PMID31534537
PMCPMC6735523
OpenAlexW2972354393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.