Evidence map›Paper›PMID 31534530›Full record

ArticleTheranostics2019

GPR124 facilitates pericyte polarization and migration by regulating the formation of filopodia during ischemic injury.

Dan-Yang Chen, Ning-He Sun, Ya-Ping Lu, Ling-Juan Hong, Tian-Tian Cui, Cheng-Kun Wang, Xing-Hui Chen, Shuai-Shuai Wang, Li-Li Feng, Wei-Xing Shi and 4 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Adhesion G protein-coupled receptors.Pharmacological reviews · 2026
    Review
  2. Review
  3. Review
  4. GPCRs as key regulators in wound healing.Frontiers in cell and developmental biology · 2026
    Review
  5. Article
  6. Eppur si muove: the dynamic brain pericyte.Fluids and barriers of the CNS · 2025
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Angiogenesis after ischemic stroke.Acta pharmacologica Sinica · 2023
    Review
  12. Astrocytes in fragile X syndrome.Frontiers in cellular neuroscience · 2023
    Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Dan-Yang ChenInstitute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Ning-He SunInstitute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Ya-Ping LuDepartment of Physiology, Nanjing Medical University, Nanjing, 211166, China.
Ling-Juan HongInstitute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Tian-Tian CuiInstitute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Cheng-Kun WangInstitute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Xing-Hui ChenDepartment of Physiology, Nanjing Medical University, Nanjing, 211166, China.
Shuai-Shuai WangKey Laboratory of Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
Li-Li FengKey Laboratory of Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
Wei-Xing ShiDepartments of Pharmaceutical, Administrative, and Basic Sciences, Schools of Pharmacy and Medicine, Loma Linda University Health, CA, 92350, USA.
Kohji FukunagaDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan.
Zhong ChenInstitute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Ying-Mei LuDepartment of Physiology, Nanjing Medical University, Nanjing, 211166, China.
Feng HanKey Laboratory of Cardiovascular & Cerebrovascular Medicine, School of Pharmacy, Nanjing Medical University, Nanjing, 211166, China.
Nanjing Medical University · CNZhejiang University · CNTohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prolonged occlusion of multiple microvessels causes microvascular injury. G protein-coupled receptor 124 (GPR124) has been reported to be required for maintaining central nervous system (CNS) angiogenesis and blood-brain barrier integrity. However, the molecular mechanisms by which GPR124 regulates pericytes during ischemia have remained elusive.

Indexed as

AnimalsBlotting, WesternBrain IschemiaCell LineCell PolarityEndothelial CellsFocal AdhesionsHEK293 CellsHumansImmunohistochemistryImmunoprecipitationLentivirusMaleMicePericytesPlasmidsADGRA2 protein, humanGPR124 protein, mouseReceptors, G-Protein-Coupleddirectional migrationfilopodiafocal adhesionsGPR124ischemia.pericytes

Identifiers

PMID31534530
PMCPMC6735362
OpenAlexW2972677877

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.