Evidence map›Paper›PMID 31534528›Full record

ArticleTheranostics2019

An all-in-one homogeneous DNA walking nanomachine and its application for intracellular analysis of miRNA.

Muren Hu, Dongsheng Mao, Xiaohao Liu, Lingjie Ren, Mengru Zhou, Xiaoxia Chen, Xiaoli Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. 3D Walking Nanomachine for Monitoring of miRNA in Living Cells.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Muren HuDepartment of General Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, P. R. China.
Dongsheng MaoCenter for Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China.
Xiaohao LiuCenter for Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China.
Lingjie RenCenter for Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China.
Mengru ZhouCenter for Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China.
Xiaoxia ChenCenter for Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China.
Xiaoli ZhuCenter for Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA walker is a powerful type of DNA nanomachine that can produce amplified signals during the "burnt-bridge"-like walking process. Despite their successful application in extracellular bioanalysis, the heterogeneity of the existing DNA walkers makes it difficult to guarantee the consistency of the results during the analysis of different cells.

Indexed as

Biosensing TechniquesCell LineCell SurvivalDNAGoldHeLa CellsHumansIn Situ Hybridization, FluorescenceLysosomesMCF-7 CellsMetal NanoparticlesMicroRNAsReverse Transcriptase Polymerase Chain ReactionDNAGoldMicroRNAsCell ImagingDNA NanomachineDNA WalkerMicroRNASignal Amplification

Identifiers

PMID31534528
PMCPMC6735375

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.