Evidence map›Paper›PMID 31534511›Full record

ArticleTheranostics2019

Heterologous and cross-species tropism of cancer-derived extracellular vesicles.

Mariangela Garofalo, Alessandro Villa, Daniela Crescenti, Monica Marzagalli, Lukasz Kuryk, Patrizia Limonta, Vincenzo Mazzaferro, Paolo Ciana

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 60 citations in OpenAlex.

  1. Review
  2. Review
  3. Does extracellular vesicle specificity truly exist?Cell communication and signaling : CCS · 2026
    Review
  4. Article
  5. Article
  6. Exosomes from Different Sources in Promoting Wound Healing.Recent advances in drug delivery and formulation · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Emerging role of exosomes in vascular diseases.Frontiers in cardiovascular medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Mariangela GarofaloDepartment of Oncology and Hemato-Oncology, Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy.
Alessandro VillaDepartment of Oncology and Hemato-Oncology, Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy.
Daniela CrescentiDepartment of Oncology and Hemato-Oncology, Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy.
Monica MarzagalliDepartment of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
Lukasz KurykTargovax Oy, Clinical Science, Helsinki, Finland.
Patrizia LimontaDepartment of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
Vincenzo MazzaferroDepartment of Oncology and Hemato-Oncology, Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy.
Paolo CianaDepartment of Oncology and Hemato-Oncology, Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy.
University of Milan · ITFondazione IRCCS Istituto Nazionale dei Tumori · ITNational Institute of Public Health · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are naturally occurring cargo delivery vesicles that have recently received considerable attention for their roles in intercellular communication in many physiological and pathological processes, including tumourigenesis. EVs generated by different tissues demonstrated specific homing: in particular, cancer-derived EVs showed a selective tropism for the tumor tissue from which the vesicles originated. For this property, EVs have been proposed as drug delivery tools for anti-cancer therapies, although the limited knowledge about their

Indexed as

Drug Delivery SystemsAdenoviridaeAnimalsCell Line, TumorColonic NeoplasmsExtracellular VesiclesFluorescent DyesHumansLung NeoplasmsMaleMiceMice, Inbred C57BLOptical ImagingTissue DistributionTropismFluorescent Dyescancer therapyextracellular vesiclesimmunocompetent cancer mouse modelsin vivo imaging.oncolytic adenoviruses

Identifiers

PMID31534511
PMCPMC6735396
OpenAlexW2968428800

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.