Evidence map›Paper›PMID 31534510›Full record

ArticleTheranostics2019

Visualizing Autophagic Flux during Endothelial Injury with a Pathway-Inspired Tandem-Reaction Based Fluorogenic Probe.

Yu Lei, Wenming Ren, Cheng-Kun Wang, Rong-Rong Tao, Huai-Jiang Xiang, Li-Li Feng, Yin-Ping Gao, Quan Jiang, Xin Li, Youhong Hu and 1 more

Open access · goldAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Yu LeiCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Wenming RenState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Cheng-Kun WangCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Rong-Rong TaoCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Huai-Jiang XiangCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Li-Li FengSchool of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Yin-Ping GaoCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Quan JiangCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Xin LiCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Youhong HuState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Feng HanCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Zhejiang University · CNChinese Academy of Sciences · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagy is a dynamic and complicated catabolic process. Imaging autophagic flux can clearly advance knowledge of its pathophysiology significance. While the most common way autophagy is imaged relies on fluorescent protein-based probes, this method requires substantial genetic manipulation that severely restricts the application. Small fluorescent probes capable of tracking autophagic flux with good spatiotemporal resolution are highly demanable.

Indexed as

AnimalsAutophagyCell LineCellular MicroenvironmentEndotheliumFluorescent DyesLysosomesMaleMiceMice, Inbred C57BLMolecular ProbesNitrosative StressPeroxynitrous AcidFluorescent DyesMolecular ProbesPeroxynitrous Acidautophagyendothelial injuryFluorescent imagingfluorescent probe

Identifiers

PMID31534510
PMCPMC6735386
OpenAlexW2967982075

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.