Evidence map›Paper›PMID 31534498›Full record

ArticleTheranostics2019

Multi-omics profiling reveals key signaling pathways in ovarian cancer controlled by STAT3.

Tiangong Lu, Armand Bankhead, Mats Ljungman, Nouri Neamati

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Tiangong LuDepartment of Medicinal Chemistry, College of Pharmacy, Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109-2800, USA.
Armand BankheadDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109-2800, USA.
Mats LjungmanDepartments of Radiation Oncology, Rogel Cancer Center, University of Michigan Medical School and Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI 48109-2800, USA.
Nouri NeamatiDepartment of Medicinal Chemistry, College of Pharmacy, Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109-2800, USA.
University of Michigan–Ann Arbor · US

Funding

gp130 as a novel therapeutic target in ovarian cancerR01CA190498 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NEAMATI, NOURI · 2015 to 2020
$1.9M
NCI NIH HHS R01 CA190498
6 · The paper itself

Abstract

Inhibiting STAT3 signaling reduces tumor progression, metastasis and chemoresistance, however the precise molecular mechanism has not been fully delineated in ovarian cancer.

methodsIn this study, we generated

resultsWe observed that deletion of

conclusionOur study presents a rich, multi-faceted summary of the molecular mechanisms impacted by

Indexed as

Signal TransductionAnimalsCell CycleCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMiceMice, KnockoutOvarian NeoplasmsProteomicsCRISPR-Cas9Multi-omic genome-wide analysisOvarian cancerSTAT3STAT3 knockout

Identifiers

PMID31534498
PMCPMC6735387
OpenAlexW2968429984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.