ReviewEvidence-based complementary and alternative medicine : eCAM2019
Comparing Verum and Sham Acupuncture in Fibromyalgia Syndrome: A Systematic Review and Meta-Analysis.
Review in Evidence-based complementary and alternative medicine : eCAM, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Brazilian Society of Rheumatology's fibromyalgia treatment guidelines - part I: monitoring and non-pharmacological management.Advances in rheumatology (London, England) · 2026Guideline
- Comparison of clinical efficacy of different acupuncture methods in the treatment of fibromyalgia: a network meta-analysis based on randomized controlled trials.Frontiers in neurology · 2026Pooled it
- Acupuncture for fibromyalgia syndrome: an overview of systematic reviews and meta-analyses.Frontiers in medicine · 2025Pooled it
- Use of Acupuncture for Adult Health Conditions, 2013 to 2021: A Systematic Review.JAMA network open · 2022Pooled it
- Efficacy of Dry Needling and Acupuncture in Patients with Fibromyalgia: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Acupuncture for the Relief of Chronic Pain: A Synthesis of Systematic Reviews.Medicina (Kaunas, Lithuania) · 2019Pooled it
- Trial
- Efficacy of Acupuncture in Patients with Fibromyalgia Syndrome: A Meta-Analysis.Journal of pain research · 2026Review
- The altered hypothalamic network functional connectivity in diminished ovarian reserve and regulation effect of acupuncture: a randomized controlled neuroimaging study protocol.Frontiers in endocrinology · 2025Article
- Effects of acupuncture versus placebo on clinical status and potential specific effects in Fibromyalgia: an umbrella review of 11 meta-analyses.Therapeutic advances in musculoskeletal disease · 2024Article
- Effectiveness of Complementary and Alternative Medicine in Fibromyalgia Syndrome: A Network Meta-Analysis.Journal of pain research · 2024Review
- Complementary and Alternative Medicine to Treat Fibromyalgia Symptoms. A Systematic Review.Journal of pain research · 2024Review
- Electro-Acupuncture Effects Measured by Functional Magnetic Resonance Imaging-A Systematic Review of Randomized Clinical Trials.Healthcare (Basel, Switzerland) · 2023Review
- Assessment of complementary and alternative medicine methods in the management of ankylosing spondylitis, rheumatoid arthritis, and fibromyalgia syndrome.Rheumatology international · 2023Review
- Effect of Acupuncture on Pain, Fatigue, Sleep, Physical Function, Stiffness, Well-Being, and Safety in Fibromyalgia: A Systematic Review and Meta-Analysis.Journal of pain research · 2022Review
- Article
- Effects of Physiotherapy vs. Acupuncture in Quality of Life, Pain, Stiffness, Difficulty to Work and Depression of Women with Fibromyalgia: A Randomized Controlled Trial.Journal of clinical medicine · 2021Article
- Efficacy of acupuncture in the treatment of fibromyalgia.Orthopedic reviews · 2021Review
- Pain Changes Induced by Acupuncture in Single Body Areas in Fibromyalgia Syndrome: Results from an Open-Label Pragmatic Study.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Use of Complementary and Alternative Medicine in Fibromyalgia: Results of an Online Survey.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAcupuncture is often used for relieving symptoms of fibromyalgia syndrome (FMS). Our aim is to ascertain whether verum acupuncture is more effective than sham acupuncture in FMS.
methodsWe collected RCTs to investigate the effects of verum acupuncture and sham acupuncture on pain, sleep quality, fatigue, and general status in FMS patients. The databases used for data retrieval were PubMed, Central Cochrane, EMBASE, PsycINFO, CNKI, VIP, OASIS, KoreaMed, and RISS. Selection/exclusion from the retrieved records was performed according to prespecified criteria, and the final selected records were assessed according to the Cochrane risk of bias tool. The results of the included trials were synthesized on the basis of outcomes, and subgroup analysis depended on the type of add-on sham acupuncture that was performed.
resultsTen RCTs (690 participants) were eligible, and eight RCTs were eventually included in the meta-analysis. The synthesis showed a sizable effect of verum acupuncture compared with sham acupuncture on pain relief (standardized mean difference (SMD) -0.49,
conclusionsVerum acupuncture is more effective than sham acupuncture for pain relief, improving sleep quality, and reforming general status in FMS posttreatment. However, evidence that it reduces fatigue was not found.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.