Evidence map›Paper›PMID 31534437›Full record

ArticleMediators of inflammation2019

Electronegative LDL from Rabbits Fed with Atherogenic Diet Is Highly Proinflammatory.

Po-Yuan Chang, Jou-Hsiang Pai, Yu-Sheng Lai, Shao-Chun Lu

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Po-Yuan ChangCardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.
Jou-Hsiang PaiDepartment of Biochemistry and Molecular Biology, National Taiwan University College of Medicine, Taipei, Taiwan.
Yu-Sheng LaiDepartment of Biochemistry and Molecular Biology, National Taiwan University College of Medicine, Taipei, Taiwan.
Shao-Chun LuDepartment of Biochemistry and Molecular Biology, National Taiwan University College of Medicine, Taipei, Taiwan.ORCID https://orcid.org/0000-0002-3297-1245
National Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electronegative low-density lipoprotein (LDL(-)) has been found in the plasma of familial hypercholesterolemia and acute myocardial infarction and has been implicated in atherosclerosis and cardiovascular disease. However, less is known about the involvement of LDL(-) in atherosclerosis-related inflammation. This study aims at investigating the inducibility of LDL(-) by atherogenic diet in rabbits and at exploring the proinflammatory potential of the diet-induced LDL(-) in macrophages. Rabbits were fed with an atherogenic diet; LDL was isolated from plasma by NaBr density gradient ultracentrifugation and was then resolved into nLDL and LDL(-) by anion-exchange chromatography. Isolated nLDL and LDL(-) were directly used or incubated with 10

Indexed as

AnimalsBlotting, WesternCell Line, TumorDiet, AtherogenicHumansInterleukin-1betaInterleukin-6Lipoproteins, LDLMacrophagesMaleNF-kappa BRabbitsTHP-1 CellsTumor Necrosis Factor-alphaIL1B protein, humanInterleukin-1betaInterleukin-6Lipoproteins, LDLNF-kappa Boxidized low density lipoproteinTumor Necrosis Factor-alpha

Identifiers

PMID31534437
PMCPMC6724430
OpenAlexW2969979318

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.