ArticleNature protocols2019
Preparation, functionalization and characterization of engineered carbon nanodots.
Article in Nature protocols, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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Who cites it
34 citing papers in PubMed, 161 citations in OpenAlex.
- Biochemical Structure Evolved Pyridine-Activated Carbon Dots Co-Assembly as Precision Antitumor Nanozyme.Angewandte Chemie (International ed. in English) · 2026Article
- Carbon nanodot precursors enable ultrahigh-loading copper single-atom catalysts for oxygen reduction reaction.RSC advances · 2026Article
- Iodine-doped carbon dots for fluorescence/computed tomography imaging and photodynamic therapy of tumor cells.RSC advances · 2026Article
- Multifunctional Glycine-Carbon Dots Protect Against Arsenic Hepatotoxicity Through Redox Balance and PI3K/AKT Activation.International journal of nanomedicine · 2026Article
- Biological Activity Evaluation of Natural Carbon Dots Against Clostridium perfringens.Chemistry & biodiversity · 2026Article
- Impact of Proteins on the Cellular Uptake of Carbon Nanodots.ACS omega · 2025Article
- Precursor-dependent photoluminescence diversity in carbonized polymer dots: the luminophores and crosslinking.National science review · 2025Review
- Carbon Dot-Linked Hydrogel for TAMs Transform: Spatiotemporal Manipulation to Reshape Tumor Microenvironment.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Carbon Dots with Antioxidant Capacity for Detecting Glucose by Fluorescence and Repairing High-Glucose Damaged Glial Cells.Journal of fluorescence · 2025Article
- Carbon Nanodots-Based Polymer Nanocomposite: A Potential Drug Delivery Armament of Phytopharmaceuticals.Polymers · 2025Review
- Theranostic Applications of Taurine-Derived Carbon Dots in Colorectal Cancer: Ferroptosis Induction and Multifaceted Antitumor Mechanisms.International journal of nanomedicine · 2025Article
- Carbon Dots: A Review with Focus on Sustainability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Size-dependent activity of carbon dots for photocatalytic HNanoscale · 2023Article
- Microwave-assisted one-step synthesis of water-soluble manganese-carbon nanodot clusters.Communications chemistry · 2023Article
- Editorial for the Special Issue Entitled "Carbon-Based Quantum Dots".Nanomaterials (Basel, Switzerland) · 2023Article
- Immunomodulatory biomaterials for implant-associated infections: from conventional to advanced therapeutic strategies.Biomaterials research · 2022Review
- Amine-Rich Carbon Dots as Novel Nano-Aminocatalytic Platforms in Organic Synthesis.European journal of organic chemistry · 2022Article
- Carbon Nanodots from an In Silico Perspective.Chemical reviews · 2022Review
- Neutral Red-carbon nanodots for selective fluorescent DNA sensing.Analytical and bioanalytical chemistry · 2022Article
- Transfer of Axial Chirality to the Nanoscale Endows Carbon Nanodots with Circularly Polarized Luminescence.Angewandte Chemie (International ed. in English) · 2022Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carbon-based dots (CDs) and their functionalized (nano)composites have recently attracted attention due to their seemingly easy preparation and numerous potential applications, ranging from those in the biomedical field (i.e., imaging and drug delivery) to those in (opto)electronics (i.e., solar cells and LEDs). This protocol details step-by-step procedures for synthesis, purification, functionalization and characterization of nitrogen-doped carbon nanodots (NCNDs), which we have been preparing for the past few years. First, we describe the bottom-up synthesis of NCNDs, starting with the use of molecular precursors (arginine (Arg) and ethylenediamine (EDA)) and making use of microwave-assisted hydrothermal heating. We also provide guidelines for the purification of these materials, through either dialysis or low-pressure size-exclusion chromatography (SEC). Second, we outline post-functionalization procedures for the surface modification of NCNDs, such as alkylation and amidation reactions. Third, we provide instructions for the preparation of NCNDs with different properties, such as color emission, electrochemistry and chirality. Given the fast evolution of preparations and applications of CDs, issues that might arise from artifacts, errors and impurities should be avoided. In this context, the present protocol aims to provide details and guidelines for the synthesis of high-quality nanomaterials with high reproducibility, for various applications. Furthermore, specific needs might require the CDs to be prepared by different synthetic procedures and/or from different molecular precursors, but such CDs can still benefit from the purification and characterization procedures outlined in this protocol. The sample preparation takes various time frames, ranging from 4 to 18 d, depending on the adopted synthesis and purification steps.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.