Evidence map›Paper›PMID 31534227›Full record

ArticleNature2019

Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth.

Yan Shao, Samuel C Forster, Evdokia Tsaliki, Kevin Vervier, Angela Strang, Nandi Simpson, Nitin Kumar, Mark D Stares, Alison Rodger, Peter Brocklehurst and 2 more

4 registry-linked trialsOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 633 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
633citing papers in PubMed, 7 pooled it
43.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05803577 unknown statusnot on this mapstarted 2021, after this paper: background citation

Preterm Infants: Microbiome Establishment, Neuro Cross-talk, and Origins

TypeobservationalSponsorUniversity College CorkRan2021 to 2025Enrolled91ConditionsPrematurity, Microbial Colonization
NCT06282952 narecruitingnot on this mapstarted 2026, after this paper: background citation

Section-Born Infants and SUccessful Health Outcomes After Fecal Microbiota Transplantation (SISU-FMT)

TypeinterventionalSponsorOulu University HospitalRan2026 to 2036Enrolled460ConditionsFecal Microbiota Transplantation, Cesarean Section, Overweight and ObesityArmsDonor-derived fecal microbiota transplantation
NCT06424691 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Infant Restore: Investigating the Efficacy of a Microbiome Analysis, Education, and Recommendation Program in Improving Infant Gut Health

TypeinterventionalSponsorSeeding IncRan2023 to 2025Enrolled100ConditionsMicrobiota, Eczema, Microbiome, Gut MicrobiomeArmsTailored Recommendations, Consult Call, Email Series
NCT07333482 narecruitingnot on this mapstarted 2026, after this paper: background citation

Flourish Study: A Randomized, Three-Arm Longitudinal Clinical Study of Microbiome-Guided Interventions in Cesarean-Born Infants

TypeinterventionalSponsorSeeding IncRan2026 to 2028Enrolled250ConditionsMicrobiota, Gut Microbiome, Eczema, MicrobiomeArmsTailored Recommendations, Consult Call, Educational Email Series
3 · Its place in the literature

Who cites it

633 citing papers in PubMed, 7 syntheses or guidelines pooled it, 1,023 citations in OpenAlex.

  1. Pooled it
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  11. Improving immune-related health outcomes post-cesarean birth with a gut microbiome-based program: A randomized controlled trial.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
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573 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Yan ShaoHost-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK.
Samuel C ForsterHost-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK.
Evdokia TsalikiInstitute for Global Health, University College London, London, UK.
Kevin VervierHost-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK.
Angela StrangInstitute for Global Health, University College London, London, UK.
Nandi SimpsonInstitute for Global Health, University College London, London, UK.
Nitin KumarHost-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK.
Mark D StaresHost-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK.
Alison RodgerInstitute for Global Health, University College London, London, UK.
Peter BrocklehurstBirmingham Clinical Trials Unit, University of Birmingham, Birmingham, UK.
Nigel FieldInstitute for Global Health, University College London, London, UK. nigel.field@ucl.ac.uk.
Trevor D LawleyHost-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK. tl2@sanger.ac.uk.
University College London · GBWellcome Sanger Institute · GBMonash University · AUUniversity of Birmingham · GB

Funding

Wellcome TrustWellcome Trust WT101169MA
6 · The paper itself

Abstract

Immediately after birth, newborn babies experience rapid colonization by microorganisms from their mothers and the surrounding environment

Indexed as

Gastrointestinal MicrobiomeCesarean SectionFemaleHumansInfant, NewbornInfant, Newborn, DiseasesInfectious Disease Transmission, VerticalOpportunistic InfectionsPregnancy

Identifiers

PMID31534227
PMCPMC6894937
OpenAlexW2973821866

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.